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Toxic Susceptibility

Male/Female Differences

Edward J. Calabrese (Autor)

Buch | Hardcover

336 Seiten

1985
John Wiley & Sons Inc (Verlag)
978-0-471-80903-6 (ISBN)

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A critical assessment of the animal models of human clinical and population-based studies that highlight the physiological and biochemical differences between male-female responses to toxic substances. Focuses on the organ systems that are especially sensitive to toxicants and pollutants. Investigates the extent to which the pregnant state may alter a susceptibility to toxic substances, with particular emphasis on alterations in drug metabolism. Shows the significance such findings have for regulatory agencies concerned with environmental health.

Partial table of contents: SEX DIFFERENCES IN BIOCHEMICAL/PHYSIOLOGICAL PROCESSES. Absorption: Gastrointestinal Tract. Plasma Protein Binding. PREGNANCY. Physiological Changes. Protein Binding. Drug Metabolism. SEX DIFFERENCES TO LIVER TOXINS. Ethionine. Orotic Acid. Carbon Tetrachloride. SEX DIFFERENCES TO RENAL TOXINS. Structural/Functional Differences Between Male and Female Rat Kidney. Petroleum. INORGANIC CONTAMINANTS. Ammonia. Cadmium. Chromium. ORGANIC CONTAMINANTS. Pesticides. Mycotoxins. DRUGS. Ethyl Alcohol. Narcotic Analgesics. Barbiturates. Mild Analgesics. Anticonvulsants. CNS Stimulants. Lithium. Diazepines. Local Anesthetics. ORAL CONTRACEPTIVES. Drug Metabolism. Carbon Disulfide. ENDOGENOUS AND RELATED SUBSTANCES. Vitamin C. Testosterone. SUMMARY. Sex Differences and Animal Extrapolation. Sex Differences in Humans. Safety Factors. Index.

Reihe/Serie	Environmental Science and Technology Series
Zusatzinfo	illustrations, bibliography, index
Verlagsort	New York
Sprache	englisch
Maße	160 x 240 mm
Gewicht	595 g
Themenwelt	Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie
	Naturwissenschaften ► Biologie ► Biochemie
	Sozialwissenschaften ► Soziologie ► Gender Studies
ISBN-10	0-471-80903-9 / 0471809039
ISBN-13	978-0-471-80903-6 / 9780471809036
Zustand	Neuware