Frontiers of Biostatistical Methods and Applications in Clinical Oncology -

Frontiers of Biostatistical Methods and Applications in Clinical Oncology

Buch | Hardcover
438 Seiten
2017 | 1st ed. 2017
Springer Verlag, Singapore
978-981-10-0124-6 (ISBN)
117,69 inkl. MwSt
This book presents the state of the art of biostatistical methods and their applications in clinical oncology. Many methodologies established today in biostatistics have been brought about through its applications to the design and analysis of oncology clinical studies. This field of oncology, now in the midst of evolution owing to rapid advances in biotechnologies and cancer genomics, is becoming one of the most promising disease fields in the shift toward personalized medicine. Modern developments of diagnosis and therapeutics of cancer have also been continuously fueled by recent progress in establishing the infrastructure for conducting more complex, large-scale clinical trials and observational studies. The field of cancer clinical studies therefore will continue to provide many new statistical challenges that warrant further progress in the methodology and practice of biostatistics. This book provides a systematic coverage of various stages of cancer clinical studies. Topics from modern cancer clinical trials include phase I clinical trials for combination therapies, exploratory phase II trials with multiple endpoints/treatments, and confirmative biomarker-based phase III trials with interim monitoring and adaptation. It also covers important areas of cancer screening, prognostic analysis, and the analysis of large-scale molecular data in the era of big data.

Shigeyuki Matsui, Professor, Department of Biostatistics, Nagoya University Graduate School of Medicine, smatsui@med.nagoya-u.ac.jp, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan John Crowley, President and CEO, Cancer Research and Biostatistics, johnc@crab.org, 1730 Minor Ave STE 1900  Seattle, WA 98101-1468

1. Phase I clinical trials.- 2. Phase II clinical trials.- 3. Phase III clinical trials.- 4. Evaluation of surrogate endpoints.- 5. Disease Screening/development of diagnosis.- 6. Analysis of omics data (genomic signature developments etc).- 7. Causal inference in clinical trials and observational studies.

“I strongly recommend that those statisticians working in the clinical oncology field check out these articles. Several were of use to me and I know that others will find them to be of use as well.” (David E. Booth, Technometrics, Vol. 60 (3), 2018)

Erscheinungsdatum
Zusatzinfo 89 Illustrations, black and white; XIII, 438 p. 89 illus.
Verlagsort Singapore
Sprache englisch
Maße 155 x 235 mm
Themenwelt Mathematik / Informatik Mathematik Wahrscheinlichkeit / Kombinatorik
Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Studium Querschnittsbereiche Epidemiologie / Med. Biometrie
Sozialwissenschaften Soziologie Empirische Sozialforschung
Schlagworte Biostatistics • cancer clinical trials • Clinical oncology • Design and Analysis of Clinical Trials • Statistical Analysis of Omics Data
ISBN-10 981-10-0124-3 / 9811001243
ISBN-13 978-981-10-0124-6 / 9789811001246
Zustand Neuware
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