Addiction Reviews 2008, Volume 1141

George R. Uhl, M.D., Ph.D, is with the National Institutes of Health, Molecular Neurobiology Research Branch, in Baltimore, Maryland. His expertise covers Genetics, Neuroscience and Molecular Biology.

Preface: George R. Uhl. Introduction: Nora D. Volkow.

Part I: Mechanisms of Addiction:.

1. Drug Addiction and the Memory Systems of the Brain: T.W. Robbins, K.D. Ersche, and B.J. Everitt.

2. Protein Kinases and Addiction: Anna Lee and Robert Messing.

3. Correlating Human and Animal Studies of Cocaine Abuse and Gene Expression: Melinda E. Lull, Willard M. Freeman, Kent E. Vrana, and Deborah C. Mash.

4. Genes and Molecules that can Potentiate or Attenuate Models of Psychostimulant Dependence: Relevance of Data from Animal Models to Human Addiction: Minae Niwa, Yijin Yan, and Toshitaka Nabeshima.

5. Implication of Activated Astrocytes in the Development of Drug Dependence: Differences between Methamphetamine and Morphine: Minoru Narita, Masami Suzuki, Naoko Kuzumaki, Mayumi Miyatake, and Tsutomu Suzuki.

Part II: Related Conditions:.

6. Chronic Stress, Drug Use, and Vulnerability to Addiction: Rajita Sinha.

7. ADHD and Smoking: From Genes to Brain to Behavior: Francis Joseph McClernon and Scott Haden Kollins.

8. An Update on Substance Use and Treatment following Traumatic Brain Injury: David P. Graham and Aaron L. Cardon.

9. Molecular Mechanisms of Fat Preference and Overeating: Dany Gaillard, Patricia Passilly-Degrace, and Philippe Besnard.

Part III: Imaging:.

10. Nonhuman Primate Neuroimaging and the Neurobiology of Psychostimulant Addiction: Leonard L. Howell and Kevin S. Murnane.

11. Abuse of Amphetamines and Structural Abnormalities in Brain: Steven Berman, Joseph O’Neill, Scott Fears, George Bartzokis, and Edythe D. London.

Part IV: Treatment:.

12. Antagonists at Metabotropic Glutamate Receptor Subtype 5: Structure Activity Relationships and Therapeutic Potential for Addiction: F. Ivy Carroll.

13. Disrupting Nicotine Reinforcement: From Cigarette to Brain: Jed E. Rose.

14. Substance Abuse Vaccines: Frank M. Orson, Berma M. Kinsey, Rana A. K. Singh, Yan Wu, Tracie Gardner, and Thomas R. Kosten.

15. Predicting Treatment Outcome in Stimulant Dependence: Martina Reske and Martin P. Paulus.

16. Risk Evaluation and Mitigation Strategies for Drugs with Abuse Liability: Public Interest, Special Interest, Conflicts of Interest and the Industry Perspective: Curtis Wright IV, Sidney Schnoll, and David Bernstein.

Part V: Epidemiology:.

17. Drug Addiction in China: Lin Lu and Xi Wang.

Part VI: Genetics:.

18. Molecular Genetics of Addiction and Related Heritable Phenotypes: Genome Wide Association Approaches Identify “Connectivity Constellation” and Drug Target Genes with Pleiotropic Effects: George R. Uhl, Tomas Drgon, Catherine Johnson, Chuan-Yun Li, Carlo Contoreggi, Judith Hess, Daniel Naiman, and Qing-Rong Liu.

Index of Contributors