Encyclopedia of Medical Immunology

Professor Ian Mackay is an Honorary Professional Research Fellow of Monash University, Australia, and member of the Department of Biochemistry and Molecular Biology. In a career spanning over six decades, with over 700 publications, Professor Mackay has gained international recognition as a pioneer in the area of autoimmunity; with his research contributing to the development of immunosuppressive treatment for autoimmune diseases. In recognition of his service to medical research, Prof. Mackay was included in the 1981 Australia Day Honours list and was appointed as a Member of the Order of Australia. In 2001 he was awarded the Centenary Medal for service to Australian society and science in biochemistry and molecular biology. Dr. Rose is the Director of Center for Autoimmune Disease Research and a Professor in the Department of Pathology (with joint appointment in Department of Medicine), the Johns Hopkins University School of Medicine and a Professor in the W. Henry Feinstone Department of Molecular Microbiology and Immunology, the Johns Hopkins University Bloomberg School of Public Health. Dr. Rose also served as the Chairman of the Autoimmune Diseases Coordinating Committee of the National Institutes of Health and a principal advisor to the former U.S. NIH Director Dr. Elias A. Zerhouni. He was the Chairman of the W. Henry Feinstone Department of Molecular Microbiology and Immunology of the Johns Hopkins University Bloomberg School of Public Health for more than a decade. Dr. Rose’s pioneering studies on autoimmune thyroiditis and myocarditis helped to initiate the modern era of research on autoimmune diseases. Dr. Rose and his colleagues have continued to contribute to our understanding of autoimmunity, including the first demonstration of the genetic factors responsible for predisposition to autoimmune disease in animals and more recent investigations on the influence of infection and environmental agents in the initiation of autoimmune disease in genetically predisposed animals. Dr. Rose is the co-author of the textbook The Autoimmune Diseases (now 3rd edition) and former Editor-in-Chief of Clinical Immunology. He is currently the Editor-in-Chief of The Year in Immunology

B cell development and repertoire sel: B cell central tolerance: controlling self-reactive B cells in the bone marrow.- B cell tolerance.- B cell trafficking.- B1 cells.- BCR signaling.- CS and SHM.- MZB cells.- Plasma Cells.- Regulatory B cells.- Repertoire selection.- TFH help.- Cardiovascular/systemic inflammation: Atherosclerosis and cytokines.-Autoantibodies and atherosclerosis.- Autoantibodies to endothelial cells.- Autoimmune disease and premature atherosclerosis.- Autoimmune heart disease animal models.- Autoimmune myocarditis and pericarditis.- Cell adhesion molecules.- Dendritic cells and atherosclerosis.- Endothelial cells and inflammation.- Immune mediated mechanisms of the metabolic syndrome.- Lymphocytes in Atherosclerosis.- Macrophages, Oxidative stress and Atherosclerosis.- Mechanisms of endothelial activation.- Neutrophils in endothelial damage.- Platelets, atherosclerosis and immunity.- Viral myocarditis.- Gut: Celiac disease.- Overview of theGut microbiome.- Overview on IBD.- Overview on mucosal immunity.- Liver: Adaptive immune cells in the liver.- AIH: clinical + systemic manifestations and treatment.- AIH: Pathogenesis, association with other syndromes.- Animal models of AIH.- Animal models of hepatitis B and C.- Gestational Alloimmune Liver Disease.- Immune response during acute and chronic Hepatitis B.- Immune response during acute and chronic Hepatitis C.- Immunosuppression in clinical liver transplantation.- Innate immune cells in the liver.- KC and tolerance.- Liver transplantation tolerance in animal models.- Liver vasculature and microvasculature.- LSEC and tolerance.- PBC genetics.- PBC: clinical + systemic manifestations and treatment.- Primary T Cell activation in the liver.- PSC: clinical + systemic manifestations and treatment.- The hepatic lymphatic system.- Transplantation for auto immune diseases.- Transplantation for chronic viral hepatitis.- Tregs in the liver.- Ultrastructure of the liver sinusoid.- Lymphocytes activation T, B, NK: B7/CD28 family.- Bcl-2 family.- CD40.- CD5.- Chemokines.- CTLA4-Ig.- Cytotoxic T cells.- FcRIIb.- GTPases.- IL-21.- Interleukin 6.- LAT.- mTOR.- NFAT.- NFkB.- NK cell activation.- PI3K.- PKCtheta.- PTPN22.- Rho/Rac GTPases.- SHIP.- T cell memory.- Paraneoplastic: Cancer and dermatomyositis.- Cancer and Fever.- Cancer and joint pain.- Cancer and nephrotic syndrome.- Cancer and neuropathies.- Cancer and the CNS.- Cancer and thrombosis.- Cancer therapies and autoimmunity.- Paraneoplastic Syndromes, an overview.- Tumor Infiltrating T cells.- Tumor Macrophages.- Resolution of Inflammation: Anti-oxidants.- CD5.- CTLA 4.- EICOSANOIDS (prostaglandins, leucotrienes, and related compounds).- Fas/fas ligand.- Fibrosis.- Nitric oxide.- Polymorphonuclear Leucocytes (PMN)/neutrophils.- Resolution of Inflammation.- TGFbeta.- Kidney: Anti-GBM GN.- Autoimmune disease.- Autoimmune Kidney Disease and Pregnancy.- Autoimmunity and Inflammation in Diabetic Nephropathy.- Complement regulation in the Kidney.- IgA Nephropathy.- Immune System and the Kidney.- Impact of Recurrent Autoimmune Diseases in Renal Transplant Outcomes.- Indications for Biopsy in Autoimmune GN.- Pathogenesis of Lupus Nephritis and New Approaches to Treatment.- Proteinuric Kidney Diseases: Importance of Blood Pressure Control.- Scleroderma Renal Crisis.- Spectrum of Minimal Change Disease to Focal Segmental Glomerulosclerosis.- Translational aspects of MN.- TTP and the Kidney.- Vasculitits and the Kidney (ANCA, etc).- Regulatory lymphocytes T, B, other: Regulatory B cells.- Tregs: Regulatory T cells.- Rheumatic Disease: APLS- Mechanism of thrombosis.- APLS- treatment.- APLS-Clinical Manifestations.- Autoinflammatory Syndromes.- Complement in rheumatic diseases.- Diagnosis and Treatment of Lupus Nephritis.- Environment and autoimmunity.- Epigenetics in autoimmunity.- Immunodeficiency in Autoimmune diseases.- Juvenile diseases: Arthritis treatment in children (incl. pathogenesis, presentation & treatment).- Juvenile diseases: Genetics of JIA.- Juvenile diseases: Juvenile arthritis syndromes.- Juvenile diseases: Kawasaki syndrome.- Juvenile diseases: SLE-children.- microRNA in autoimmunity.- Myositis pathogenesis.- Myositis-Dermatomyositis, Polymyositis, inclusion body myositis, and autoantibodies.- Myositis: Juvenile myositis.- Nephritogenic autoantibodies in SLE.- RA- clinical features.- RA- extraarticular manifestations.- RA-animal models.- RA-autoantibodies.- RA-genetics.- RA-treatment.- RA: Biologics in the treatment of RA.- RA: Small molecules.- Raynauds phenomenon.- Sarcoidosis.- Scleroderma-genetics.- Scleroderma: Pathogenesis and Clinical Manifestations.- Sjogren's syndrome.- SLE - Clinical Trials in SLE.- SLE - Discoid SLE.- SLE - Novel targets in SLE Essay.- SLE-animal models.- SLE-autoantibodies.- SLE-clinical features and diagnosis.- SLE-gender and hormonal influences.- SLE-genetics.- SLE-pathogenesis.- SLE-pregnancy.- SLE-skin.- SLE-treatment.- SLE: Congenital heart block and neonatal lupus.- SLE: Mixed connective tissue disease (MCTD).- Spondyloarthritis: Ankylosing Spondylitis.- Spondyloarthritis: Psoriatic arthritis.- Spondyloarthritis: Reactive Arthritis.- Treatment (current and upcoming) of scleroderma.- Vasculitis: Bechets.- Vasculitis: Churg-Strauss syndrome.-Vasculitis: Cutaneous vasculitis (hypersensitivity vasculitis).- Vasculitis: Giant cell arteritis.-Vasculitis: Henoch-Schonlein purpura.- Vasculitis: Microscopic polyangiitis.- Vasculitis: Polyarteritis nodosa.- Vasculitis: Polymyalgia rheumatica.- Vasculitis: Primary CNS vasculitis.-Vasculitis: Wegenerâ??s granulomatosis.- Skin and Alopecia: Alopecia areata.- Autoimmune Blistering Diseases.- Blistering diseases: Bullous Pemphigoid.- Blistering diseases: Mucous Membrane Pemphigoid.- Blistering diseases: Linear IgA disease (LAD).- Blistering diseases: Pemphigus.- Dermatomyositis.- Erythema nodosum.- HairLoss In Lupus Erythematosus.- Inflammatory - SLE – Skin.- Inflammatory: Dermatomyositis – skin.- Inflammatory: Discoid lupus.- Inflammatory: psoriasis cutaneous.- Lichen Planopilaris.- Lichen planus.- Neutrophilic dermatoses: Sweets syndrome.- Neutrophilic dermatoses: Leukocytoclastic vasculitis.- Neutrophilic dermatoses: Pyoderma gangrenosum.- Scleroderma like conditions.- Skin and Alopecia.- Vitiligo.