The Genetic Basis of Common Diseases

Richard A. King, Jerome I. Rotter, Arno G. Motulsky (Herausgeber)

Buch | Hardcover

1096 Seiten

2002 | 2nd Revised edition
Oxford University Press Inc (Verlag)
978-0-19-512582-5 (ISBN)

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This reference work should prove relevant, not only to to the student seeking a basic understanding of a particular disease, but also to the physician and the genetic counsellor, through its its discussion of treatments and genetic risk information for families.

Since the first edition of this highly acclaimed text was published in 1992, much new knowledge has been gained about the role of genetic factors in common adult disease, and we now have a better understanding of the molecular processes involved in genetic susceptibility and disease mechanisms. The Second Edition fully incorporates these advances. The entire book has been updated and twelve new chapters have been added. Most of these chapters deal with diseases such as gallstones, osteoporosis, osteoarthrits, skin cancer, other common skin diseases, prostate cancer and migraine headaches that are seen by all physicians. Others address the genetic and molecular basis of spondyloarthropathies, lupus, hemochromatosis, IgA deficiency, mental retardation, hearing loss, and the role of mitochondrial variation in adult diseases. Chapters on the evolution of human genetic disease and on animal models add important background on the complexities of these diseases. Unique clinical applications of genetics to common diseases are covered in additional new chapters on genetic counselling, pharmacogenetics, and the genetic consequences of modern therapeutics.

PART 1: APPROACHES ; 1. Approach to Genetic Bases of Common Diseases ; 2. Molecular Genetics of Common Diseases ; 3. Genetic Epidemiologic Methods ; 4. Evolution of Human Genetic Diseases ; 5. Animal Models of Complex Genetic Disease ; 6. Genetic Counselling: History, Risk Assessment, Strategies and Ethical Considerations ; PART 2: CARDIOPULMONARY DISEASES ; 7. Genetics of Coronary Atherosclerosis ; 8. Hypertension ; 9. Chronic Obstructive Pulmonary Disease ; PART 3: IMMUNOLOGIC AND INFECTIOUS DISEASES ; 10. Genetics of Human Susceptibility to Infectious Diseases: Progress and Prospects ; 11. Genetics of Asthma and Bronchial Hyperresponsiveness ; 12. IgA Deficiency and Common Variable Immunodeficiency ; PART 4: GASTROINTESTINAL DISORDERS ; 13. Peptic Ulcer and Gastritis ; 14. Lactase Deficiency: Biological and Medical Aspects of the Adult Human Lactase Polymorphism ; 15. Inflammatory Bowel Disease ; 16. Gallstones ; 17. Chronic Liver Disease ; 18. Hereditary Hemochromatosis ; 19. Gluten-Sensitive Enteropathy ; PART 5: ENDOCRINE DISORDERS ; 20. Thyroid Disease ; 21. Type 1 Diabetes Mellitus ; 22. Type 2 Diabetes Mellitus ; 23. Obesity ; 24. Genetics of Osteoporosis ; 25. Hyperuricemia and Gout ; PART 6: GENITOURINARY DISEASES ; 26. Gynaecologic Disorders ; 27. Infertility and Pregnancy Loss ; PART 7: RHEUMATOLOGIC DISEASES ; 28. Immunology and Immunogenetics ; 29. Rheumatoid Arthritis ; 30. Seronegative Spondyloarthropathies ; 31. Genetics of Systematic Lupus Erythematosus ; 32. Genetic Basis of Primary Osteoarthritis ; 33. Common Disorders of Connective Tissue ; PART 8: CANCER ; 34. Gastrointestinal Cancer ; 35. Breast Cancer ; 36. Familial and Genetic Influences on Risk of Lung Cancer ; 37. Reproductive Organ Cancers ; 38. Skin Cancer ; 39. Prostate Cancer ; 40. Haematologic Cancer ; PART 9: NEUROPSYCHIATRIC DISORDERS ; 41. Epilepsy ; 42. Multiple Sclerosis ; 43. Alzheimer's Disease ; 44. Affective Disorders ; 45. Schizophrenia ; 46. Alcoholism ; 47. Mental Retardation ; 48. Hereditary Hearing Loss ; 49. Migraine ; PART 10: OTHER COMMON PROBLEMS ; 50. Common Skin Disease ; 51. Genetic Modulation of Aging and Longevity ; 52. Mitochondrial Defects in Common Diseases ; 53. Constitutional Chromosome Disorders in Adults ; PART 11: THERAPY ; 54. Genetic Consequences of Modern Therapeutics: Iatrogenic Mutagenesis ; 55. Pharmacogenetics, Ecogenetics and Pharmacogenomics

Erscheint lt. Verlag	28.11.2002
Reihe/Serie	Oxford Monographs on Medical Genetics ; 44
Zusatzinfo	numerous black and white photographs, figures and tables
Verlagsort	New York
Sprache	englisch
Maße	286 x 222 mm
Gewicht	2441 g
Themenwelt	Schulbuch / Wörterbuch ► Lexikon / Chroniken
	Medizin / Pharmazie ► Medizinische Fachgebiete
	Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik
	Studium ► Querschnittsbereiche ► Prävention / Gesundheitsförderung
ISBN-10	0-19-512582-7 / 0195125827
ISBN-13	978-0-19-512582-5 / 9780195125825
Zustand	Neuware