Basic Pharmacokinetics

Mohsen A. Hedaya, PharmD, PhD, is a professor at the Faculty of Pharmacy, Tanta University, Egypt, and is currently on leave to work at the Faculty of Pharmacy, Kuwait University, Kuwait. He received his Bachelor of Science in Pharmacy degree Tanta University, and his Doctor of Pharmacy and Doctor of Philosophy degrees from the University of Minnesota, USA. He joined the College of Pharmacy, Washington State University, USA, in 1993 as an Assistant Professor of Pharmaceutical Sciences. After returning to Egypt in 1999, he was promoted to the rank of associate and then full professor. He served as the Chair of the Clinical Pharmacy Department and Vice Dean for Academic Affairs at the Faculty of Pharmacy, Tanta University. Dr. Hedaya’s area of interest is pharmacokinetics. He has taught basic and advanced pharmacokinetic classes to professional pharmacy students and graduate students in Egypt, the United States, and Kuwait. His research interest includes pharmacokinetic drug interactions, drug delivery to the brain, pharmacokinetic computer simulations, and bioequivalent study design and data analysis. The computer-based and online educational materials developed by Dr. Hedaya in the area of pharmacokinetics are currently being used by more than 350 educational, research, and industrial institutions around the world.

1.Introduction to Pharmacokinetics. 2.Drug Pharmacokinetics Following Single Intravenous Bolus Administration: Drug Distribution. 3.Drug Pharmacokinetics Following a Single IV Bolus Administration: Drug Clearance. 4.Drug Pharmacokinetics Following Single IV Bolus Administration: The Rate of Drug Elimination. 5.Drug Absorption Following Extravascular Administration: Biological, Physicochemical, and Formulation Considerations. 6.Drug Pharmacokinetics Following Single Oral Drug Administration: The Rate of Drug Absorption. 7.Drug Pharmacokinetics Following Single Oral Drug Administration: The Extent of Drug Absorption. 8.Bioequivalence. 9.Drug Pharmacokinetics during Constant Rate IV Infusion, the Steady State concept. 10.Steady State during Multiple Drug Administration. 11.Renal Drug Excretion. 12.Metabolite Pharmacokinetics. 13.Nonlinear Pharmacokinetics. 14.Multicompartment Pharmacokinetic Models. 15.Drug Pharmacokinetics Following Administration by Intermittent Intravenous Infusions. 16.Physiological Approach to Hepatic Clearance. 17.Pharmacokinetics in Patients with Eliminating Organ Dysfunction. 18.Noncompartmental Approach in Pharmacokinetic Data Analysis. 19.Pharmacokinetic-Pharmacodynamic Modeling. 20.Pharmacogenetics: The Genetic Basis of Pharmacokinetic and Pharmacodynamic Variability. 21.Therapeutic Drug Monitoring. 22.Pharmacometic Applications in Drug Development and Individualization of Drug Therapy. 23.Answer to Practice Problems.