Microbiome, Immunity, Digestive Health and Nutrition

Debasis Bagchi, PhD, MACN, CNS, MAIChE, received his Ph.D. in Medicinal Chemistry in 1982. He is a Professor in the Department of Pharmacological and Pharmaceutical Sciences at the University of Houston College of Pharmacy, Houston, TX, and Chief Scientific Officer at Cepham Research Center, Piscataway, NJ, Adjunct Faculty in Texas Southern University, Houston, TX. He served as the Senior Vice President of Research & Development of InterHealth Nutraceuticals Inc, Benicia, CA, from 1998 until Feb 2011, and then as Director of Innovation and Clinical Affairs, of Iovate Health Sciences, Oakville, ON, until June 2013. Dr. Bagchi received the Master of American College of Nutrition Award in October 2010. He is the Past Chairman of International Society of Nutraceuticals and Functional Foods (ISNFF), Past President of American College of Nutrition, Clearwater, FL, and Past Chair of the Nutraceuticals and Functional Foods Division of Institute of Food Technologists (IFT), Chicago, IL. He is serving as a Distinguished Advisor on the Japanese Institute for Health Food Standards (JIHFS), Tokyo, Japan. Dr. Bagchi is a Member of the Study Section and Peer Review Committee of the National Institutes of Health (NIH), Bethesda, MD. He has published 321 papers in peer reviewed journals, 30 books, and 18 patents. Dr. Bagchi is also a Member of the Society of Toxicology, Member of the New York Academy of Sciences, Fellow of the Nutrition Research Academy, and Member of the TCE stakeholder Committee of the Wright Patterson Air Force Base, OH. He is also Associate Editor for the Journal of Functional Foods, Journal of the American College of Nutrition, and the Archives of Medical and Biomedical Research, and is also serving as Editorial Board Member of numerous peer reviewed journals, including Antioxidants & Redox Signaling, Cancer Letters, Toxicology Mechanisms and Methods, and The Original Internist, among others. Bernard William (Bill) Downs received his Bachelor of Science degree in 1975 from Pennsylvania State University. Downs simultaneously pursued his master’s degree and Ph.D. in Nutrition and Biochemistry at Immaculata University in Immaculata, PA; advanced degree not completed. He became Director of Therapeutic Nutrition for Morrison Family and Sports Medicine, Huntingdon Valley, PA from 1990 till 1996. Downs served as the Director of Technical Sales for InterHealth Nutraceuticals Inc., Benicia, CA from 1990 till 2003. He was the Director of Research and Development for Allied Nutraceutical Research, Blue Bell, PA, from 2003 till 2008. Downs served as the CEO of LifeGen Research from 2009 till 2013, Lederach, PA. Downs is Founder and CEO of Victory Nutrition International, Inc., a Research & Development Biotech Company, Lederach, PA. Downs is a member of the American Association for the Advancement of Science, the American College of Nutrition, and past member of the NY Academy of Sciences. He is on the editorial review board of the Journal of Reward Deficiency Syndrome. Downs has authored or co-authored 105 papers published in peer-reviewed journals, numerous chapters in texts and handbooks for clinicians and researchers, with patents-pending in nutraceutical biotechnology. Research publications have been on issues ranging from immunity, anemia and metabolic disorders to addictions, obsessions, compulsions, and personality disorders, among other Reward Deficiency Syndrome conditions.

I. Preface From the Editor's Desk

II. Microbiome and Human Health: An Introduction 1. Oral Microbiome: A Gateway to Human Health 2. Influence of Microbiome in Shaping the Newborn Immune System: An Overview 3. Impact of Gut Bacteria on Human Health and Diseases 4. Individual Microbiota Correction and Human Health: Programing and Reprogramming of Systemic and Local Immune Response

III. Microbiome and Digestive Health 5. The Etiology of Gut Dysbiosis and its Role in Chronic Disease 6. Role of Microbiome in the Function and Diseases of the Digestive System

IV. Microbiome and Metabolic Syndrome 7. Beneficial Role of Healthy Microbiome in Metabolic Syndrome, Obesity and Cardiovascular Health 8. The Role of the Intestinal Microbiota in Weight Loss 9. Role of Microbial Metabolites in Cardiovascular and Human Health 10. Healthy Microbiome in Metabolic Syndrome, Obesity and Cardiovascular Health: An Overview 11. Potential Role of Healthy Microbiome in Metabolic Syndrome, Obesity and Cardiovascular Health 12. Restoring Gut Biome Balance for Weight Loss: Clinical applications 13. Harnessing Gut Friendly Microbiomes to Combat Metabolic Syndrome 14. The Effect of Resveratrol-Mediated Gut Microbiota Remodeling on Metabolic Disorders

V. Microbiome and Immune Health 15. Microbiome, Immunity, Anaerobism, and Inflammatory Conditions: A Multifaceted Systems Biology Intervention 16. Preclinical Data Supports the Strong Specificity and Advertised Ability to Mitigate Immune Reactions at Mucosal Sites VI. Microbiome and Cognitive Health 17. Achieving Dopamine Homeostasis to Combat Brain-Gut Functional Impairment: Behavioral and Neurogenetic Correlates of Reward Deficiency Syndrome (RDS) 18. Influence of Gut Microbial Flora in Body’s Serotonin Turnover and Its Associated Diseases 19. The Connection Between Diet, Gut Microbes and Cognitive Decline 20. Role of the Gut Microbiome in Rett Syndrome

VII. Microbiome, Dermal Health and Wound Healing 21. Skin Microbiota and its Role in Health and Disease with an Emphasis in Chronic Wound Development and Wound Healing

VIII. Microbiome and Cancer 22. Healthy Gut Microbiome in the Prevention of Colorectal Cancer

IX. Microbiome, Arthritis and Multiple Sclerosis 23. Regulatory Roles of the Microbiome in Arthritis, Fibromyalgia, and Multiple Sclerosis

X. Environmental Pollutants and Gut Microbiome 24. Microplastic Exposure and Gut Microbiome

XI. Molecular and Immunological Mechanisms Associated with Healthy Gut Microbiome Functions 25. Role of the Gut Microbiome and Probiotics for Tuberculosis Prevention and Management 26. Lactic Acid Bacteria-Based Beverages in Promotion of Gastrointestinal Health 27. Prospective role of prebiotics and probiotics on gut immunity 28. Gut Brain Communication: A novel application of Probiotics 29. Beneficial Effects of Flaxseed on Gut Microbiota 30. Dietary Flavonoids and Gut Microbiota 31. Role of Mushroom Polysaccharides in Improving Gut health and Prevent Associated Diseases

XII. Microbiome and Immunomodulatory Peptides 32. Food derived immunomodulatory peptides: Science to applications

XIII. Study Design and Statistical Interpretation 33. Clinical Intervention Study Design and Statistical Methodology: Statistical Approaches for Pre–Post Studies

XIV. Commentary from the Editor's Desk 34. Conclusion and Editor's Commentary