SPECTROPHOTOMETRIC AND SPECTROSCOPIC STUDIES OF NOVEL ANTI-CANCER DRUG

Understanding the charge transfer process between bioactive molecules and inorganic or organic molecules is significant as this interaction can be used to interpret bioactive molecule-receptor interactions. A comprehensive spectrophotometric study has been performed to explore the complexation chemistry of the Crizotinib (CZT) with pi - acceptor. The molecular structure, spectroscopic characteristics and the interactive modes have been deduced from UV-Vis and FT-IR spectra. The binding ratio of complexation has been determined to be 1:1 for acceptor with CZT. Benesi-Hildebrand method was applied to estimate the spectroscopic and physical data. The association constant (K), extinction coefficient (_max), ionization potential (IP), energy of the charge transfer complex (ECT), resonance energy (RN), dissociation energy (W) and standard Gibbs energy ( G0) have been computed. Based upon the obtained spectroscopic data, the plausible CT mechanism between CZT and acceptor was proposed.