Effect of Glycemic Control on Vitamin B12

Diabetes Mellitus is an endocrine disorder and the complications arising from the disease is the leading cause of death worldwide. Vitamin B12 is a water soluble vitamin and its deficiency results in disruption of methylation process which leads to accumulation of serum and intracellular homocysteine and methylmalonic acid which gets accumulated in the myelin sheath and leads to formation of abnormal fatty acids, resulting in neurological manifestations. Glycated Hb is used as a guideline to check the status of patient's glycemic control for preceding 3 months. The objective of this study was to correlate HbA1c and Vitamin B12 status in Type 2 Diabetes patients. Mean serum Vitamin B12 in the study group was 218.17±118.3 and HbA1c was 7.94±1.99. Positive correlation existed between HbA1c and Vitamin B12 with p value 0.0013 and r value 0.3161 which is statistically significant (p value <0.05)