Novel Drug Delivery Systems for Phytoconstituents

Editors Madhu Gupta has research experience pertaining to drug delivery to nanoformulations for magical molecule delivery, bioligands for targeting of bioactives and drug moiety, biopolymers, cancer nanomedicine, as well as topical delivery that is carried out at the Department of Pharmaceutical Sciences, Dr. H.S. Gour Central University, Sagar. Dr. Gupta has done her B. Pharm (Gold Medalist), M. Pharm, PhD in Pharmaceutics with experience of more than 12 years in academics, administrative functions, and research in areas of pharmaceutical nanotechnology and targeted drug delivery related to cancer, fungal infection, and psoriasis. Presently she is working as an officer on special duty to Vice- Chancellor in Delhi Pharmaceutical Sciences and Research University. Along with teaching and research, she is Chief Operating Officer of World Class Skill Centre courses, PRO, website In-charge, IQAC in addition to much other managerial work. She is pioneer scientist in the fields of nanotechnology and drug delivery. She has judiciously exploited bioligands for targeting of bioactives and drug moiety. She has over 40 research publications to her credit published in journals of high scientific impact and contributed 18 chapters in various renowned books and to several international and national books. Dr. Gupta has H-index of 12, i10-index of 14, and more than 600 citations. She has been awarded by various national and international conferences in the form of best oral and poster presentation award and other national and international awards. She has supervised 15 MPharm students. Dr. Gupta has availed several prestigious fellowships and awards SRF AICTE (NDF), JRF (AICTE), Travel grant awards (DST, ICMR, INSA, and DBT, MPCST), Prof. G.P. Nair Award (2004), and Prof. C.S. Chauhan Award (2004). She has her research work at BioAsia Innovation Award—2012, Grace India Awards, Youth Education Award 2018, and Young Researcher Award. She has successfully completed one project that is funded by MPCST Bhopal. She is the nominee of CPCSEA and also an active member of various pharmaceutical bodies such as APTI and others. She is a reviewer of various journals of repute. She has attended various conferences/ seminars/workshops/FDPs as organizer/coordinator/resource person/participant. Dr. Gupta and her team have been selected for funding of one start-up. Durgesh Nandini Chauhan completed her BPharm degree in Pharmacy from the Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal, India, and her MPharma (pharmaceutical sciences) in pharmaceutics from Uttar Pradesh Technical University, currently Dr. A.P.J. Abdul Kalam Technical University, Lucknow, in 2006. Mrs. Durgesh Nandini Chauhan has 10 years of academic (teaching) experience from Institutes of India in pharmaceutical sciences. She taught such subjects as pharmaceutics, pharmacognosy, traditional concepts of medicinal plants, drug-delivery phytochemistry, cosmetic technology, pharmaceutical engineering, pharmaceutical packaging, quality assurance, dosage form designing, and anatomy and physiology. She is member of the Association of Pharmaceutical Teachers of India, SILAE: Società Italo-Latinoamericana di Etnomedicina (The Scientific Network on Ethnomedicine, Italy), and so forth. Her previous research work includes Penetration Enhancement Studies on Organogel of Oxytetracycline HCL. She also attended AICTE-sponsored Staff Development Program on “Effects of Teaching and Learning Skills in Pharmacy-Tool for Improvement of Young Pharmacy Teachers” and workshop on Analytical Instruments. She has written more than 10 publications in national and international journals, 13 book chapters, and authored 2 books: Optimization and Evaluation of an Organogel and Plant and Marine Based Phytochemicals for Human Health: Attributes, Potential, and Use. She is also active as a reviewer for several international scientific journals and active participant in national and international conferences such as Bhartiya Vigyan Sammelan and International Convention of Society of Pharmacognosy. Presently she is part of the Ishita Research Organization, Raipur, India, as a freelance writer and guiding pharmacy, Ayurvedic, and science students in their research projects. Vikas Sharma is Associate Professor and Principal Shri Rawatpura Sarkar Institute of Pharmacy Datia, India. Dr. Sharma obtained his BPharm from Jiwaji University Gwalior, MPharm in Pharmacognosy, and PhD from Dr. H.S. Gour Central University Sagar, India. Dr. Sharma has more than 12 years of teaching and research experience. He has made significant contributions in the area of medicinal plant research. He has been working on evidence-based validation of medicinal plants and pharmacological screening of herbal drugs. Dr. Sharma works on marker and biomarker analysis of herbs for quality evaluation. He has also made significant contributions to development of chemical profiling of extracts and formulation through TLC, HPTLC, and LC-MS. He is supervising scientific research of the postgraduation and the doctoral level. He has written several researches and review paper in reputed journals and has contributed several chapters in books on pharmaceutical and indigenous drugs. He is a member of various professional and academic bodies like Association of Pharmaceutical Teachers of India (APTI) and the Society of Pharmacognosy. Nagendra Singh Chauhan obtained his MPharm and PhD from Department of Pharmaceutical Sciences, Dr. H.S. Gour University, Sagar in 2006 and 2011. He has around 14 years of research experience. He is presently working as Senior Scientific Officer Grade-II and Government Analyst at Drugs Testing Laboratory avam Anusandhan Kendra, Raipur, Chhattisgarh, India. He has professional expertise in natural product isolation. He also has hands-on experience in various techniques like extraction, isolation, and purification of natural products from plant extracts using various chromatographic techniques for separation of compounds including column, LC-MS, chromatography, preparative TLC, and structure elucidation of natural products with the help of various techniques like UV, mass, IR, and NMR. He is well versed with the design, conduct, and data treatment of various in vivo experiments like aphrodisiac, antidiabetic, anti-stress, hair growth, BPH, hepatoprotective, and reproductive parameters. He has written more than 50 articles published in national and international journals and 20 book chapters. He has more than 1400 citations with h-index 21 and i10 index of 32 (Google scholar) and scopus h-index 15; 669 citations. He is a member of various professional and academic bodies like Society of Pharmacognosy, International Natural Product Sciences Taskforce (INPST) Society, SILAE: Società Italo-Latinoamericana di Etnomedicina (The Scientific Network on Ethnomedicine, Italy), Institutional Human ethical committee, and the Association of Pharmaceutical Teachers of India (APTI).

Contents

Preface ..................................................................................................................................................... vii

Editors ....................................................................................................................................................... ix

Contributors .............................................................................................................................................. xi

Section I Drug Delivery Systems

1. Novel Drug Delivery Systems for Phytoconstituents: Current and Future Prospects .............. 3

Vikas Sharma, Madhu Gupta, Durgesh Nandini Chauhan, Nagendra Singh Chauhan,

Ramesh K.Goyal, and Kamal Shah

2. Nanocarriers Systems and Their Application for the Delivery of Different

Phytoconstituents ........................................................................................................................... 9

Ebru Altuntaş, Gülgün Yener, and Burcu Özkan

3. Liposome-Based Nanocarrier System for Phytoconstituents .................................................... 45

Ngoc Thuy Trang Le, Linh Phuong Tran Pham, Diem Huong Tran Nguyen, Ngoc Hoang Le,

Tuong Vi Tran, Cuu Khoa Nguyen, and Dai Hai Nguyen

4. Phytosomes as Novel Carriers of Herbal Extracts ...................................................................... 69

Sevgi Güngör, Özlem Akbal-Dağıstan, Evren Algın Yapar, Murat Kartal, and Yıldız Özsoy

5. Lipid-Based Nanoparticles: SLN, NLC, and MAD .................................................................... 81

Rita Cortesi, Paolo Mariani, Markus Drechsler, and Elisabetta Esposito

Section II Application of Phytodrug Delivery

6. Phytosomes as Useful Drug Delivery Systems for Cosmeceutical Application ...................... 105

Francesca Froiio, Agnese Gagliardi, Massimo Fresta, Donato Cosco, and Donatella Paolino

7. Novel UV Filtering Agents for Next-Generation Cosmetics: From Phytochemicals to

Inorganic Nanomaterials ..............................................................................................................121

Aditya Arya and Jayanti Jha

8. Development of Ethosome Formulation for Topical Therapeutic Applications ..................... 137

Mansoureh Nazari Vishkaei, Mohamed B. Khadeer Ahamed, and Amin Malik Shah

Abdul Majid

9. Application of Phytodrug Delivery in Anticancer Therapy ..................................................... 157

Xiuhua Wang and Shirui Mao

Section III Phytomolecule Drug Delivery

10. Improved Silymarin Characteristics for Clinical Applications by Novel Drug

Delivery Systems ........................................................................................................................... 195

Maryam Tabarzad, Fatemeh Ghorbani-Bidkorbeh, and Tahereh Hosseinabadi

11. Silymarin—A Scintillating Phytoantioxidant: Clinical Applications and Bio-delivery

Problems ........................................................................................................................................ 223

Aditya Arya, Subhojit Paul, and Anamika Gangwar

12. Innovative Delivery Systems for Andrographolide Delivery ................................................... 241

A. C. Santos, J. A. D. Sequeira, F. Veiga, A. Figueiras, and A. J. Ribeiro

13. Polymeric Colloidal Carriers for Natural Polyphenolic Compounds ......................................261

Maria Rosaria Lauro, Teresa Musumeci, Francesca Sansone, Giovanni Puglisi, and

Rosario Pignatello

14. Drug Delivery Systems for the Controlled Delivery of Berberine ........................................... 283

Rosario Pignatello, Simona Cianciolo, and Agata K. Giuffrida

15. Lipid-Based Nanoformulations from Plants for Sustainable Drug Delivery ......................... 301

Ilaria Clemente, Ilaria Colzi, and Sara Falsini

16. Nanotechnological-Based Drug Delivery System for Magical Molecule Curcumin:

Delivery, Possibilities and Challenges .........................................................................................313

Madhu Gupta, Vikas Sharma, Durgesh Nandini Chauhan, Nagendra Singh Chauhan,

Kamal Shah, and Ramesh K. Goyal

Index .......................................................................................................................................................333