Malaria (eBook)

Front Cover 1
Immunology and Immunization 4
Copyright Page 5
Table of Contents 6
List of Contributors 10
Preface 12
Contents of Volumes 1 and 2 14
Contents of Babesiosis 16
Chapter 1. The Isolation of Malaria Parasites and Their Constituents 20
I. INTRODUCTION 20
II. ISOLATION OF PLASMODIA AND THEIR CONSTITUENTS 21
III. CONCLUSIONS 70
REFERENCES 71
Chapter 2. Methods for Measuring the Immunological Response to Plasmodia 86
I. INTRODUCTION 86
II. THE ANTIBODY RESPONSE AGAINST SPOROZOITES 87
III. THE ANTIBODY RESPONSE AGAINST EXOERYTHROCYTIC FORMS 92
IV. THE ANTIBODY RESPONSE TO BLOOD STAGES 93
REFERENCES 120
Chapter 3. The Vertebrate Host's Immune Response to Plasmodia 130
I. INTRODUCTION 130
II. THE IMMUNE RESPONSE AGAINST PLASMODIA 133
III. SUMMARY AND HYPOTHESIS: PROBABLE MECHANISMS OF IMMUNITY TO PLASMODIA 166
REFERENCE 169
Chapter 4. Immunization against Sporozoites 182
I. INTRODUCTION 182
II. IMMUNIZATION OF RODENTS AGAINST SPOROZOITE-INDUCED MALARIA 183
Ill. IMMUNIZATION OF SIMIAN HOSTS AGAINST SPOROZOITE-INDUCED MALARIA 198
IV. IMMUNIZATION OF HUMANS AGAINST SPOROZOITE-INDUCED MALARIA 206
V. CONCLUSIONS 213
VI. PERSPECTIVES 215
ACKNOWLEDGMENTS 216
REFERENCES 216
Chapter 5. Immunization against Exoerythrocytic Stages of Malaria Parasites 222
I. INTRODUCTION 222
II. IMMUNE RESPONSIVENESS TO EXOERYTHROCYTIC STAGES 227
III. DISCUSSION 240
ACKNOWLEDGMENTS 244
REFERENCES 245
Chapter 6. Immunization against Asexual Blood-Inhabiting Stages of Plasmodia 250
I. INTRODUCTION 250
II. IMMUNIZATION AGAINST BIRD MALARIA PARASITES 252
III. IMMUNIZATION AGAINST RODENT MALARIA PARASITES 253
IV. IMMUNIZATION AGAINST SIMIAN MALARIA PARASITES 257
V. IMMUNIZATION AGAINST HUMAN MALARIA PARASITES 264
VI. SUMMARY AND CONCLUSION 271
REFERENCES 276
Chapter 7. Infectiousness and Gamete Immunization in Malaria 282
I. INTRODUCTION 282
II. AVIAN MALARIA (Plasmodium gallinaceum) 284
III. RODENT MALARIA (Plasmodium yoelii) 291
IV. SIMIAN MALARIA 292
V. HUMAN MALARIA 296
VI. CONCLUSIONS 309
REFERENCES 312
Appendix 1: Prospects for Development of Vaccines against Plasmodium falciparum Infection 318
Appendix 2: The Roles of Vaccination in the Strategy of Malaria Control 336
Appendix 3: Prospects for Malaria Blood Stage Vaccine 340
Appendix 4: Manufacturing Aspects of Antiplasmodial Vaccine Production 344
Appendix 5: The Agency of International Development Program for Malaria Vaccine Research and Development 350
Appendix 6: The Great Neglected Diseases of Mankind 354
Index 358