Hormonal Proteins and Peptides (eBook)

Front Cover 1
Hormonal Proteins and Peptides 4
Copyright Page 5
Table of Contents 6
List of Contributors 8
Preface 10
Contents of Volume II 12
Chapter 1. The Chemistry of Glycoproteins 16
Text 16
References 28
Chapter 2. The Chemistry of Pituitary Thyrotropin 32
I. Introduction 32
II. Preparation of Bovine TSH 34
III. Purification of Human TSH 39
IV. The Subunits of Bovine TSH and their Linear Amino Acid Sequences 41
V. The Carbohydrate Portion of Bovine TSH 51
VI. A Comparison of the Molecular Parameters of Bovine TSH Determined Directly and as Deduced from the Sequence 54
VII. The Chemical and Biological Relationships between TSH, LH, and HCG (Human Chorionic Gonadotropin) 59
VIII. Comparative Studies—Human TSH 64
IX. Problems and Possibilities 67
Acknowledgments 69
References 69
Chapter 3. The Chemistry of the Interstitial Cell-Stimulating Hormone of Ovine Pituitary Origin 74
I. Introduction 74
II. Purification of Ovine ICSH 76
III. Physical Properties of Ovine ICSH 81
IV. Chemical Properties of Ovine ICSH 83
V. The Subunit Nature of ICSH 89
VI. Structural Studies on the ICSH Subunits 97
VII. Comments on the Heterogeneity of ICSH 111
VIII. Concluding Remarks 112
Acknowledgments 113
References 113
Chapter 4. The Biology of Pituitary Interstitial Cell-Stimulating Hormone 116
I. Introduction 117
II. Gonadotropic Factors of the Pituitary Gland 119
III. Biological Effects of ICSH in the Female 122
IV. Role of ICSH in Pregnancy 130
V. Formation and Maintenance of Corpus Luteum 140
VI. Biological Effects of ICSH in the Male 152
VII. Extragonadal Actions of ICSH 156
VIII. Regulation of ICSH Secretion 158
IX. Metabolism of ICSH 164
X. Effects of ICSH on Gonadal Metabolism 167
XI. Concluding Remarks 172
References 174
Chapter 5. Chemistry of Human Chorionic Gonadotropin 186
I. General 186
II. Methods of Purification of HCG 188
III. Physicochemical Properties 191
IV. Chemical Composition 194
V. Amino and Carboxy Terminal Analyses 195
VI. Quaternary Structure of HCG 196
VII. Investigation of the Carbohydrate Units in HCG 200
VIII. Amino Acid Sequence of HCG 207
IX. General Considerations 210
References 212
Chapter 6. Chemistry and Biosynthesis of Thyroid Iodoproteins 216
I. Introduction: Definitions and Classifications 216
II. Chemistry of Thyroid Iodoproteins 217
III. Biosynthesis of Thyroid Iodoproteins 234
References 250
Author Index 258
Subject Index 275