Prostaglandins, Platelets, Lipids (eBook)

Front Cover 1
Prostaglandins, Platelets, Lipids: New Developments in Atherosclerosis 4
Copyright Page 5
Table of Contents 6
Acknowledgments 8
Introduction 10
Chapter 1. The Biological Importance and Therapeutic Potential of Prostacyclin 14
Objectives 14
Vascular Effects of Prostacyclin 16
Antithrombotic and Hemostatic Effects of Prostacyclin 17
Prostacyclin-Thromboxane A2 Balance and Antithrombotic Therapy 22
Prostacyclin, Fatty Acids and Thrombosis 25
Thromboxane A2-Prostacyclin Balance in Other Pathologicsd States 27
Therapeutic Uses of Prostacyclin 28
References 30
Self-Evaluation Quiz 43
Chapter 2. Rationale for the Suppression of Platelet Aggregation and Thrombosis by Dietary Manipulation of Fatty Acids 46
Objectives 46
3 Series PG Products: Synthetic Pathway and Platelet Effects 48
The Potential of PGD3 as an Antithrombotic Agent 49
Eicosapentaenoic Acid as a Potential Antithrombotic Substance 51
1 Series PG Products and Platelet Aggregation —Mechanism of Action 54
Conclusion 57
References 58
Self-Evaluzation Quiz 60
Chapter 3. Prostaglandins and Hypertension 62
Objectives 62
Vascular Prostaglandins and Antihypertensive Mechanisms 66
Renal Prostaglandins and Antihypertensive Mechanisms 70
Summary 79
Acknowledgments 79
References 79
Self-Evaluation Quiz 85
Chapter 4. Antiplatelet Agents in the Prevention of Acute Coronary Events 88
Objectives 88
References 104
Self-Evaluation Quiz 105
Chapter 5. Role of Platelets in Stroke and Transient Ischemic Attack 108
Objectives 108
Thrombosis and Clinical Complications of Atherosclerosis 108
Thrombosis and the Clinical Complications of Atherosclerosis 114
Mechanisms in Thrombosis 117
Summary 120
References 122
Self-Evaluation Quiz 128
Chapter 6. Cardiovascular Actions of Prostacyclin in Man 132
Objectives 132
Hemodynamic Changes Induced by Prostacyclin (PGI2) 132
Prostacyclin Therapy for Peripheral Arterial Disease 135
Prostacyclin and Angina Pectoris 138
Side Effects of PGI2 Therapy 140
Conclusion 141
References 141
Self-Evaluation Quiz 143
Chapter 7. A Specific Inhibitor of Thrombin: Effects on the Arachidonic Acid Cascade 144
Objective 144
References 149
Self-Evaluation Quiz 150
Discussion 152
Answers to Self-Evaluation Quizzes 162
Subject Index 164