Muscle and Nonmuscle Motility (eBook)

Front Cover 1
Muscle and Nonmuscle Motility 4
Copyright Page 5
Table of Contents 6
Contributors 8
Preface 10
Contents of Volume 2 12
Chapter 1. Molecular Basis of Contraction in Cross-Striated Muscles and Relevance to Motile Mechanisms in Other Cells 14
I. Introduction 15
II. Structure of Muscle Fibers 16
III. Protein Components of the Filaments 37
IV. Changes in the Band Pattern of Muscle during Contraction and Stretch 43
V. Molecular Structure of the Filaments 56
VI. Molecular Changes during Contraction and in Rigor 79
VII. Some Biochemical and Physiological Implications of the Structural Results 92
VIII. Structural Details of the Cross-Bridge Mechanism 103
IX. Outstanding Problems and Future Work 112
References 113
Chapter 2. Macromolecular Assembly of Myosin 118
I. Introduction 118
II. Assembly of Myosin Filaments 127
III. Assembly of Copolymers of Different Myosins (Hybridization) 152
References 157
Chapter 3. Macromolecular Assembly of Actin 164
I. Introduction 165
II. G-F Transformation of Actin 166
III. Structure of F-Actin 180
IV. Conformation and Interaction of Actin Monomer 192
V. Interaction of F-Actin with Regulatory Proteins and Myosin 201
VI. Actin and Motility 214
VII. Concluding Remarks 222
References 224
Chapter 4. Regulation of Contractility 230
I. Introduction 230
II. One Aspect of the Troponin Mechanism: The Role of Troponin T 231
III. General Aspects of the Regulatory Mechanism in Vertebrate Smooth Muscle 234
IV. Characteristics of Aorta Leiotonin 236
V. Troponin in Ascidian Smooth Muscle 240
VI. A Regulatory Factor in Slime Mold 242
VII. Concluding Remarks 243
References 244
Chapter 5. The Regulation of Cytoplasmic Ca2+ Concentration in Muscle and Nonmuscle Cells 246
I. Introduction 247
II. The Sarcoplasmic Reticulum of Skeletal Muscle 251
III. The Transport of Ca2+ by Cardiac Sarcoplasmic Reticulum 270
IV. The Ca2+ Transport Activities of Cardiac Sarcolemma 271
V. Smooth Muscle 276
VI. The Regulation of Cytoplasmic Ca2+ Concentration in Nonmuscle Cells 282
References 347
Index 372