Thorium-232 and Uranium-238 -

Thorium-232 and Uranium-238 (eBook)

The Toxicology of Radioactive Substances
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2013 | 1. Auflage
150 Seiten
Elsevier Science (Verlag)
978-1-4831-5301-8 (ISBN)
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The Toxicology of Radioactive Substances, Volume 4: Thorium-232 and Uranium-238 deals with the toxic properties of two radioactive elements, thorium-232 and uranium-238, as well as their soluble and insoluble compounds. Emphasis is placed on their biological effects and the late sequelae of their administration, especially in the case of insoluble compounds. Some of the results of laboratory studies on the acute and chronic effects of the very poorly soluble uranium compound U3O8 are presented. This volume is comprised of 12 chapters and opens with an overview of certain aspects of the toxicology of insoluble compounds of thorium-232 and uranium-238, followed by a discussion on the comparative toxicity of soluble and insoluble compounds of thorium-232. Subsequent chapters explore the absorption, distribution, and excretion of certain soluble compounds of natural thorium; the behavior of thorium dioxide in rats after intratracheal and intraperitoneal administration; the effect of thorium dioxide on the peripheral blood of rats; and photometric determination of low amounts of thorium in biological materials. Changes in the peripheral blood following chronic and acute poisoning with U308 are also considered. This book will be of interest to chemists and toxicologists.
The Toxicology of Radioactive Substances, Volume 4: Thorium-232 and Uranium-238 deals with the toxic properties of two radioactive elements, thorium-232 and uranium-238, as well as their soluble and insoluble compounds. Emphasis is placed on their biological effects and the late sequelae of their administration, especially in the case of insoluble compounds. Some of the results of laboratory studies on the acute and chronic effects of the very poorly soluble uranium compound U3O8 are presented. This volume is comprised of 12 chapters and opens with an overview of certain aspects of the toxicology of insoluble compounds of thorium-232 and uranium-238, followed by a discussion on the comparative toxicity of soluble and insoluble compounds of thorium-232. Subsequent chapters explore the absorption, distribution, and excretion of certain soluble compounds of natural thorium; the behavior of thorium dioxide in rats after intratracheal and intraperitoneal administration; the effect of thorium dioxide on the peripheral blood of rats; and photometric determination of low amounts of thorium in biological materials. Changes in the peripheral blood following chronic and acute poisoning with U308 are also considered. This book will be of interest to chemists and toxicologists.

Front Cover 1
Thorium-232 and Uranium-238 4
Copyright Page 5
Table of Contents 6
CHAPTER 1. CERTAIN ASPECTS OF THETOXICOLOGY OF INSOLUBLE COMPOUNDS OF THORIUM-232 AND URANIUM-238 8
References 15
CHAPTER 2. COMPARATIVE TOXICITY OF SOLUBLEAND INSOLUBLE COMPOUNDS OF THORIUM-232 16
Summary 25
References 25
CHAPTER 3. ABSORPTION, DISTRIBUTION AND EXCRETION OF CERTAIN SOLUBLE COMPOUNDS OF NATURAL THORIUM 27
Summary 35
References 36
CHAPTER 4. THE BEHAVIOUR OF THORIUM DIOXIDEIN RATS AFTER INTRATRACHEAL AND INTRAPERITONEAL ADMINISTRATION 37
Summary 47
References 47
CHAPTER 5. THE EFFECT OF THORIUM DIOXIDE ON THE PERIPHERAL BLOOD OF RATS 49
Red Blood 52
White Blood 56
Granulocytes 56
Lymphocytes 57
Thrombocytes 61
Summary 63
References 63
CHAPTER 6. THE EFFECT OF THORIUM DIOXIDE ON ARTERIAL PRESSURE AND THRESHOLD OF STIMULATION OF THE NERVE-MUSCLE APPARATUS IN RATS 65
Effect of Thorium Dioxide on Arterial Pressure in Rats 66
Effect of Thorium Dioxide on the Stimulation Threshold of the Nerve-muscle Apparatus of Animals 69
Summary 71
References 71
CHAPTER 7. MORPHOLOGICAL CHANGES IN THE LUNGS AND OTHER ORGANS IN RATS ON INTRATRACHEAL ADMINISTRATION OFTHORIUM DIOXIDE 73
First Group 75
Second Group 78
Third Group 79
Fourth Group 82
Summary 87
References 88
CHAPTER 8. PHOTOMETRIC DETERMINATION OF LOWAMOUNTS OF THORIUM IN BIOLOGICAL MATERIALS 90
References 93
CHAPTER 9. THE EFFECT OF URANOUS-URANIC OXIDE(U3O8) IN EXPERIMENTAL WORK 94
Prolonged Introduction via the Gastro-intestinal Tract 95
Introduction of U3O8 into the Trachea 96
Subcutaneous Administration of U3O8 in Rabbits 105
Summary 106
References 107
CHAPTER 10. CHANGES IN THE PERIPHERAL BLOOD FOLLOWING CHRONIC AND ACUTE POISONING WITH U3O8 108
Changes in the Peripheral Blood after Oral Administration of U3O8 109
Changes in the Peripheral Blood after Intratracheal Administrationof U3O8 109
Summary 114
References 115
CHAPTER 11. THE EFFECT OF U3O8 ON THE BODY OF THE PREGNANT FEMALE AND THE FOETUS 116
Content of Uranium in the Tissues of the Placenta and Embryos and in the Organs of the Mother 117
Distribution of Uranium in the Organs of Newborn Animals 119
Distribution of Uranium in the Organs of Puppies Feeding on the Milk of Burdened Mothers 119
Effect of Chronic Burdening on the Ability of the Female to Multiply 122
Effect of Chronic Intoxication with U3O8 on Foetal Development in the Intrauterine and Early Extrauterine Periods 123
Effect of Poisoning of Rabbits with U3O8 in the Suckling Period on the Development of the Newborn 124
Effect of Poisoning with Uranyl Nitrate on the Development of the Foetus 124
Summary 125
References 125
CHAPTER 12. PATHOMORPHOLOGICAL CHANGES IN ANIMALS FOLLOWING ACUTE AND CHRONIC POISONING WITH U3O8 127
Acute Poisoning with Uranium by the Intratracheal Route 128
Chronic Poisoning with U3O8 by Different Routes of Administration 132
Summary 140
References 142
INDEX 144

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