Biosynthesis and Secretion of Milk / Diseases (eBook)

Front Cover 1
Biosynthesis and Secretion of Milk / Diseases 4
Copyright Page 5
Table of Contents 6
LIST OF CONTRIBUTORS 10
PREFACE 12
CONTENTS OF OTHER VOLUMES 14
PART I: BIOSYNTHESIS OF MILK 16
Chapter 1. General Metabolism Associated with the Synthesis of Milk 18
I. Introduction 18
II. Cytological and Biochemical Interrelationships 21
III. Intermediary Metabolism of the Mammary Gland 27
IV. Conclusions 42
References 42
Chapter 2. Biosynthesis of Milk Fat 46
I. Introduction 46
II. De Novo Fatty Acid Synthesis 47
III. Triglyceride Synthesis 76
IV. Synthesis of Other Milk Lipids 83
References 84
Chapter 3. Biochemistry of Lactose and Related Carbohydrates 92
I. Introduction 92
II. Biochemistry of Lactose 93
III. Biochemistry of Carbohydrates Other than Lactose 111
IV. Summary 123
Acknowledgments 124
References 124
Chapter 4. Biosynthesis of the Milk Proteins 130
I. Introduction 130
II. Origin of the Milk Proteins 131
III. Overall Mechanism of Protein Synthesis 136
IV. Studies on the Pathway of Milk Protein Synthesis 137
V. Cellular Structures for Milk Protein Synthesis 147
VI. Cellular Control Mechanisms 149
VII. Control Mechanisms in Milk Protein Synthesis 152
VIII. Biological Functions of the Milk Proteins 156
IX. Summary and Conclusion 157
Acknowledgments 157
References 158
Chapter 5. Cytological Aspects of Milk Formation and Secretion 162
I. Introduction 162
II. Cell Structure—Milk Synthesis and Secretion 176
III. Variation among Alveoli in the Lactating Gland 200
Acknowledgments 203
References 203
Chapter 6. Membranes of the Mammary Gland 208
I. Introduction 208
II. Methods of Isolation 210
III. Membrane Composition 221
IV. Membrane-Bound Enzymes of Milk Synthesis 234
V. Role of Membranes in Milk Secretion 237
VI. Concluding Remarks 243
VII. Addendum 243
Acknowledgments 244
References 245
PART II: DISEASES OF THE MAMMARY GLAND AND LACTATION 252
Chapter 7. Pathophysiology of Prolaetin Secretion in Man 254
I. Introduction 254
II. Evidence Concerning the Nature of Human Prolaetin 255
III. Assays for Human Prolaetin in Serum 259
IV. Hypothalamic Regulation of Prolaetin Secretion in Man 262
V. Clinical Disorders of Prolactin Secretion 276
VI. Gynecomastia 279
VII. Possible Extramammary Actions of Prolactin 280
References 281
Chapter 8. Microbial Diseases of the Mammary Gland 286
I. Description, Incidence, and Causal Organisms 286
II. Establishment of Infection 294
III. Response of the Mammary Gland to Infection 312
IV. Effect of Infection on Milk Secretion 321
References 328
Chapter 9. Ketosis 334
I. General Aspects 335
II. Glucose Metabolism 341
III. Lipid Metabolism 349
IV. Ketone Body Metabolism 355
V. Role of the Endocrine Glands 360
VI. Nutritional Aspects 362
VII. Therapy 365
VIII. Prevention 366
References 367
Chapter 10. Parturient Hypocalcemia, Hypomagnesemia, Mastitis–Metritis–Agalactia Complex of Swine 372
I. Parturient Hypocalcemia 372
II. Hypomagnesemia 398
III. Mastitis–Metritis–Agalactia Complex of Swine (MMA) 399
References 399
Chapter 11. Mammary Tumors in Mice 408
I. Introduction 408
II. Inbred Strains and Preneoplastic and Neoplastic Mammary Lesions 409
III. Factors Influencing Mammary Neoplasia in Mice 411
IV. Conclusions and Future Directions 422
References 423
AUTHOR INDEX 430
SUBJECT INDEX 455