Pharmaceutical Aspects of Cancer Chemotherapy (eBook)

Front Cover 1
Pharmaceutical Aspects of Cancer Chemotherapy 4
Copyright Page 5
Table of Contents 12
Series preface 6
Preface 8
Contributors 10
Chapter 1. Absorption and distribution of anticancer drugs 14
Introduction 14
Pharmacokinetics of orally administered anticancer drugs 19
CCNU 29
Concluding remarks 34
Acknowledgement 35
References 35
Further reading 39
Chapter 2. Cytotoxic drug delivery 40
Rationale for cytotoxic drug delivery 40
Characteristics of an ideal drug delivery system 41
Classification of drug delivery systems 41
Strategies for targeting cytotoxic drug delivery systems 41
Vesicular systems 43
Microparticulate systems 52
Soluble macromolecular carriers 62
Summary 63
References 64
Further Reading 66
Chapter 3. Drug interactions with cytotoxic agents 67
Drug interaction mechanisms 68
Examples of interactions with specific cytotoxics 71
Summary and conclusions 75
References 80
Further reading 82
Chapter 4. Handling cytotoxic drugs 83
Methods of absorption 84
Are there reliable tests to monitor environmental exposure? 84
Equipment 86
Techniques and procedures 91
Acknowledgement 92
References 93
Further reading 94
Chapter 5. Stability of solutions of anticancer drugs 95
Introduction 95
Stability-indicating assays 97
Factors affecting drug stability 97
The anticancer drugs 101
Conclusion 109
Appendix 109
References 115
Further reading 116
Chapter 6. Development and production of cytotoxic drug formulations for Phase I trials 117
Formulation strategy from receipt of raw material 117
Methods of stabilisation, identification of specific reaction mechanisms and compatibility with excipients 124
Pilot formulation studies 125
Stability studies 126
Preclinical toxicology: animal studies 127
Manufacture of dosage forms for clinical studies 128
Specific problems encountered with some compounds formulated at the CRC Formulation Unit 130
References 143
Further reading 144
Index 146