Molecular Endocrinology (eBook)

Front Cover 1
Molecular Endocrinology 4
Copyright Page 5
Dedication 6
Table of Contents 8
Preface to the Second Edition 10
Preface to the First Edition 12
Part 1: Introduction and General Endocrinology 14
Chapter 1. Introduction 16
I. Definitions 17
II. Hormone-Target Relationships 18
III. Chemical Nature 20
IV. Biological Activity 22
V. Control 26
VI. Hormonal Control of Calcium Metabolism 28
References 35
Chapter 2. Classical Endocrinology 37
I. Introduction 38
II. Hypothalamus and Pituitary Gland 38
III. Adrenal Glands 44
IV. The Thyroid Gland 53
V. Reproduction 57
VI. Gastrointestinal Hormones 66
References 73
Chapter 3. Non-Classical Endocrinology 75
I. Introduction 76
II. Growth Factors 76
III. Invertebrate Hormones 97
IV. Plant Hormones 103
V. Prospective 109
References 109
Part 2: Receptors 114
Chapter 4. Kinetics 116
I. Introduction 117
II. Receptor Assays 118
III. Kinetics 119
IV. lodination 126
V. Receptor Preparations 127
VI. Summary 128
References 129
Chapter 5. Nuclear Receptors 131
I. Introduction 132
II. Structure 132
III. Families 137
IV. Metabolism 140
V. Nongenomic Actions 147
VI. Summary 149
References 150
Chapter 6. Membrane Receptors 161
I. Introduction 162
II. Enzyme-Linked Receptors 162
III. Serpentine Receptors 175
IV. Fibronectin-Like Receptors 182
V. Miscellaneous Membrane Receptors 188
VI. Ion Channel Receptors 189
VII. Receptor Metabolism 196
VIII. Miscellaneous Topics 204
IX. Summary 207
References 209
Chapter 7. Receptor Regulation 235
I. Introduction 236
II. Receptor Number 236
III. Receptor Affinity and Specificity 239
IV. Endogenous Antagonists 241
V. Transduction Uncoupling 242
VI. Developmental Regulation 244
VII. Summary 246
References 247
Part 3: Transduction 254
Chapter 8. G Proteins and Cyclic Nucleotides 256
I. Introduction 257
II. Criteria for Second Messengers 257
III. G Proteins 258
IV. Cyclic AMP Pathway 270
V. Cyclic GMP Pathway 280
VI. Cyclic CMP Pathway 281
VII. Transcellular Signaling 281
VIII. Summary 282
References 282
Chapter 9. Calcium, Calmodulin, and Phospholipids 295
I. Introduction 296
II. Criteria for Second Messengers 296
III. The Phosphoinositide Effect 300
IV. Other Phospholipids 320
V. Summary 327
References 329
Chapter 10. Miscellaneous Second Messengers 345
I. Polyamines 346
II. Oligosaccharides 352
III. Cellular pH 354
IV. Cytoskeleton 355
V. Summary 363
References 363
Chapter 11. Phosphorylation and Other Nontranscriptional Effects of Hormones 371
I. Introduction 372
II. Phosphorylation 372
III. Glucose Transport 388
IV. Summary 391
References 391
Part 4: Gene Regulation by Hormones 400
Chapter. 12 Hormonally Regulated Transcription Factors 402
I. Introduction 403
II. Transcription Factors: General 403
III. Transcription Factors: Specific 412
IV. Specificity Problems 426
V. Mechanisms for Transcription Effects 429
VI. Hormone Response Elements 433
VII. Summary 438
References 438
Chapter 13. Modifications and Conformations of DNA and Nuclear Proteins 455
I. Introduction 456
II. Chromatin Structure 456
III. Template Activity 471
IV. Summary 476
References 477
Chapter 14. Post-transcriptional Control 486
I. Introduction 487
II. RNA Processing 487
III. Translation 490
IV. Post-translational Regulation 494
V. Summary 497
References 498
Part 5: Special Topics 504
Chapter 15. Molecular Evolution of the Endocrine System 506
I. Introduction 507
II. Hormones 507
III. Receptors 515
IV. Transducers 521
V. Transcription Factors 527
VI. Evolution of Function 528
VII. Summary 529
References 530
Chapter 16. Pathogen-Endocrine System Interactions 544
I. Introduction 545
II. Viral and Bacterial Genes 546
III. Anti-oncogenes 552
IV. Summary 555
References 556
Chapter 17. Molecular Bases of Endocrinopathies 564
I. Introduction 565
II. Hormones 565
III. Receptors 575
IV. Transduction 582
V. Transcription Factors 585
VI. Summary 586
References 586
List of Abbreviations 598
Index 608