Cellular and Molecular Renewal in the Mammalian Body (eBook)

Front Cover 1
Cellular and Molecular Renewal in the Mammalian Body 4
Copyright Page 5
Table of Contents 6
List of Contributors 12
Preface 14
Chapter 1. Approaches to the Study of Molecular and Cellular Renewal 16
I. Introduction 16
II. Cell Populations and Renewal 17
III. Subcellular Renewal 31
References 36
Chapter 2. The Metabolic Stability of Nuclear DNA 40
I. Introduction 40
II. DNA Constancy 41
III. DNA Stability 50
IV. Conclusions 52
References 53
Chapter 3. Cell Proliferation and Renewal in the Mammalian Body 60
I. Introduction 60
II. Cell Proliferation and Growth during the Embryonic and Postnatal Periods 61
III. Methods Used to Visualize and to Measure Cell Proliferation and Cell Renewal 63
IV. Classification of Cell Populations Based on Their Proliferative Behavior 79
V. Regulation of Cell Proliferation 89
References 94
Chapter 4. Cellular Content and Cellular Proliferation Changes in the Tissues and Organs of the Aging Mammal 102
I. Introduction 102
II. Changes in Numbers of Cells and Nerve Fibers 103
III. Changes in Mitotic Rates 112
IV. Changes in Mucosal Cells of the Intestine 112
V. Discussion 116
References 119
Chapter 5. RNA Molecules in Cells and Tissues, in Vivo and in Vitro 122
I. Introduction 123
II. Intracellular Sites of RNA Synthesis 123
III. Nuclear Sites of RNA Synthesis 127
IV. The Biosynthesis of RNA Molecules 128
V. Nucleic Acids of Mitochondria 139
VI. RNA Synthesis in Special Cell Systems 144
VII. RNA Synthesis over the Cell Cycle 154
References 157
Chapter 6. Turnover of Intracellular Proteins 168
I. Introduction 168
II. Proteins of the Nucleus 170
III. Turnover of Proteins in Cytoplasmic Systems 184
IV. Proteins and the Cell Cycle 193
V. Protein Metabolism in Special Cell Systems 199
References 220
Chapter 7. The Dynamics of Extracellular and Cell Surface Protein Interactions 236
I. Introduction 236
II. Epigenetic Controls Regulating Differentiation: The Problem 238
III. Outer Cell Surface Properties and Their Role in the Formation of Metazoan Systems 243
IV. Epithelial-Mesenchymal Interactions 254
V. The Extracellular Matrix Influences upon Cellular Differentiation 263
References 282
Chapter 8. Synthesis, Localization, and Renewal of Lipids in Mammalian Tissues 292
I. Introduction 292
II. Fatty Acids and Triglycerides 294
III. Cholesterol 308
IV. Sphingolipids 317
V. Phospholipids 320
VI. Brown Adipose Tissue 332
VII. Summary 336
References 336
Chapter 9. Localization, Identification, and Renewal of Carbohydrates in Tissues and Cells 346
I. Introduction 346
II. Histochemistry of Mucins 349
III. Histochemistry of Polysaccharides 368
References 381
Chapter 10. Calcification 388
Text 388
References 393
AUTHOR INDEX 396
SUBJECT INDEX 416