Neurotoxins -

Neurotoxins (eBook)

P. Michael Conn (Herausgeber)

eBook Download: EPUB
2013 | 1. Auflage
423 Seiten
Elsevier Science (Verlag)
978-1-4832-8488-0 (ISBN)
Systemvoraussetzungen
54,83 inkl. MwSt
  • Download sofort lieferbar
  • Zahlungsarten anzeigen
The exquisite simplicity and potency of toxins have made them valuable probes of neural systems. This book presents a comprehensive compilation of techniques used for the preparation, handling, and, particularly, for the use of neurotoxins. Model systems are described in which these neurotoxins have been extremely valuable in developing an understanding of the cellular and molecular basis of secretion and electrophysiological events leading to altered cell function.
Key Features
* Convenient benchtop format
* Methods presented for easy adaptation to new systems
* A virtual 'A-B-C' of commonly used and available toxins
* Comprehensive protocols included for the use of alpha toxin, apamin, batrachotoxin; botulina toxin, bungarotoxin; channel ligands: agonists and antagonists; capsaicin; charybdotoxin, ciguatoxin; Clostridium botulinum neurotoxin; cholera toxin (choleragen); conotoxin; dendrotoxin; endothelin; fasciculin; geographutoxin; latrotoxin; natural toxins; neosurgatoxin; palytoxin; pertussis toxin; resiniferatoxin; sarafotoxin; scorpion toxin; snake venom toxins
The exquisite simplicity and potency of toxins have made them valuable probes of neural systems. This book presents a comprehensive compilation of techniques used for the preparation, handling, and, particularly, for the use of neurotoxins. Model systems are described in which these neurotoxins have been extremely valuable in developing an understanding of the cellular and molecular basis of secretion and electrophysiological events leading to altered cell function. Convenient benchtop format Methods presented for easy adaptation to new systems A virtual "e;A-B-C"e; of commonly used and available toxins Comprehensive protocols included for the use of alpha toxin, apamin, batrachotoxin; botulina toxin, bungarotoxin; channel ligands: agonists and antagonists; capsaicin; charybdotoxin, ciguatoxin; Clostridium botulinum neurotoxin; cholera toxin (choleragen); conotoxin; dendrotoxin; endothelin; fasciculin; geographutoxin; latrotoxin; natural toxins; neosurgatoxin; palytoxin; pertussis toxin; resiniferatoxin; sarafotoxin; scorpion toxin; snake venom toxins

Contributors to Volume 8


Frances C.G. Alexander(12),     Protein Toxins Group, Division of Biologics, PHLS Centre for Applied Microbiology and Research, Salisbury, Wiltshire SP4 OJG, England

A.J. Anderson(29),     Department of Physiology and Pharmacology, Strathclyde Institute for Drug Research, University of Strathclyde, Glasgow G1 1XW, Scotland

M. Arita(22),     Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, Yahatanishiku, Kitakyushu 807, Japan

Johanna Balvinsdottir(7),     Department of Biological Sciences, The Royal Danish School of Pharmacy, 2100 Ø Copenhagen, Denmark

Evelyne Benoit(11),     Laboratoire de Physiologie Comparée, Unité Associée du Centre de la Recherche Scientifique, Université de Paris XI, 91405 Orsay, France

Roland Benz(1),     Lehrstuhl für Biotechnologie, Universität Würzburg, D-8700 Würzburg, Germany

Mordecai Blaustein(16),     Department of Physiology and Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201

Peter M. Blumberg(27),     Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Institutes of Health, National Cancer Institute, Bethesda, Maryland 20892

Jean-Philippe Breittmayer(17, 25),     Faculté de Médecine, Université de Nice, 06034 Nice, France

Barry S. Brewster(2),     Jerry Lewis Muscle Research Center, Department of Pediatrics and Neonatal Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London W12 ONN, England

Carlos Cerveñansky(18),     Division of Neurochemistry, Instituto de Investigaciones Biológicas Clemente Estable, 11600 Montevideo, Uruguay

Trinad Chakraborty(1),     Lehrstuhl für Mikrobiologie, Universität Würzburg, D-8700 Würzburg, Germany

Jens Dencker Christensen(7),     Department of Biological Sciences, The Royal Danish School of Pharmacy, 2100 Ø Copenhagen, Denmark

F. Clementi(6),     CNR Center of Cytopharmacology, Department of Medical Pharmacology, University of Milan, 20129 Milan, Italy

Joan X. Comella(11),     Facultat de Medicina, Estudi General de Lleida, Universitat de Barcelona, Lleida E-25006, Spain

Cyrus R. Creveling(3),     Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892

Federico Dajas(18),     Division of Neurochemistry, Instituto de Investigaciones Biológicas demente Estable, 11600 Montevideo, Uruguay

John W. Daly(3),     Laboratory of Bioorganic Chemistry, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892

Thu T. Dinh(9),     Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, Pullman, Washington 99164

A. Esparis-Ogando(6),     CNR Center of Cytopharmacology, Department of Medical Pharmacology, University of Milan, 20129 Milan, Italy

Bjarne Fjalland(7),     Department of Biological Sciences, The Royal Danish School of Pharmacy, 2100 Ø Copenhagen, Denmark

Christian Frelin(17, 25),     Institut de Pharmacologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Sophia Antipolis, 06560 Valbonne, France

Maria L. Garcia(10),     Department of Membrane Biochemistry and Biophysics, Merck Institute for Therapeutic Research, Rahway, New Jersey 07065

Margarita Garcia-Calvo(10),     Department of Membrane Biochemistry and Biophysics, Merck Institute for Therapeutic Research, Rahway, New Jersey 07065

C. Gotti(6),     CNR Center of Cytopharmacology, Department of Medical Pharmacology, University of Milan, 20129 Milan, Italy

Claude Granier(28),     Laboratoire de Biochemie, Centre National de la Recherche Scientifique, Faculté de Médecine, 13326 Marseille Cedex 15, France

John B. Harris(21),     Division of Neurobiology, School of Neurosciences, University of Newcastle upon Tyne, Medical School, Newcastle upon Tyne, NEZ 4AB, England

A.L. Harvey(29),     Department of Physiology and Pharmacology, Strathclyde Institute for Drug Research, University of Strathclyde, Glasgow Gl 1XW, Scotland

N.H. Himmelreich(20),     Department of Neurochemistry, A. V. Palladin Institute of Biochemistry, Ukrainian Academy of Sciences, 252030 Kiev, U.S.S.R.

F. Izumi(22),     Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, Yahatanishiku, Kitakyushu 807, Japan

Annette Jørgensen(7),     Department of Biological Sciences, The Royal Danish School of Pharmacy, 2100 Ø Copenhagen, Denmark

Gregory J. Kaczorowski(10),     Department of Membrane Biochemistry and Biophysics, Merck Institute for Therapeutic Research, Rahway, New Jersey 07065

H. Kobayashi(22),     Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, Yahatanishiku, Kitakyushu 807, Japan

Susan F. Law(26),     Department of Pharmacology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104

Anne-Marie Legrand(11),     Institut Territorial de Recherches Médicales Louis Malardé, Associé à l’Institute Pasteur, Papeete, Tahiti, Polynésie, Francaise

Ida J. Llewellyn-Smith(13),     Center for Neuroscience and Department of Medicine, Flinders University School of Medicine, Bedford Park, South Australia 5042, Australia

Karsten Lollike(7),     Institute of Medical Physiology and Biotechnology, Center for Signal Peptide Research, The Panum Institute, University of Copenhagen, 2200 N Copenhagen, Denmark

Erwann P. Loret(28),     Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331

Jane B. Minson(13),     Center for Neuroscience and Department of Medicine, Flinders University School of Medicine, Bedford Park, South Australia 5042, Australia

Françis Miranda(28),     Laboratoire de Biochemie, Centre National de la Recherche Scientifique, Faculté de Médecine, 13326 Marseille Cedex 15, France

Jordi Molgo(4,...

Erscheint lt. Verlag 22.10.2013
Sprache englisch
Themenwelt Sachbuch/Ratgeber Natur / Technik Naturführer
Medizin / Pharmazie
Naturwissenschaften
Technik
ISBN-10 1-4832-8488-3 / 1483284883
ISBN-13 978-1-4832-8488-0 / 9781483284880
Haben Sie eine Frage zum Produkt?
EPUBEPUB (Adobe DRM)

Kopierschutz: Adobe-DRM
Adobe-DRM ist ein Kopierschutz, der das eBook vor Mißbrauch schützen soll. Dabei wird das eBook bereits beim Download auf Ihre persönliche Adobe-ID autorisiert. Lesen können Sie das eBook dann nur auf den Geräten, welche ebenfalls auf Ihre Adobe-ID registriert sind.
Details zum Adobe-DRM

Dateiformat: EPUB (Electronic Publication)
EPUB ist ein offener Standard für eBooks und eignet sich besonders zur Darstellung von Belle­tristik und Sach­büchern. Der Fließ­text wird dynamisch an die Display- und Schrift­größe ange­passt. Auch für mobile Lese­geräte ist EPUB daher gut geeignet.

Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen eine Adobe-ID und die Software Adobe Digital Editions (kostenlos). Von der Benutzung der OverDrive Media Console raten wir Ihnen ab. Erfahrungsgemäß treten hier gehäuft Probleme mit dem Adobe DRM auf.
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen eine Adobe-ID sowie eine kostenlose App.
Geräteliste und zusätzliche Hinweise

Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.

Mehr entdecken
aus dem Bereich
Über 440 Vogelarten Europas, mehr als 1.600 Abbildungen EXTRA: Mach …

von Volker Dierschke

eBook Download (2024)
Franckh-Kosmos Verlags-GmbH & Co. KG
13,99