The Human Oncogenic Viruses

Cytogenetics of the Leukemias and Lymphomas.- 1. Introduction.- 2. Methodologie Background and Considerations.- 3. Chromosome Changes in Chronic Myelocytic Leukemia (CML).- 4. Oncogenes, the Ph, and CML.- 5. Karyotypic Aspects of the Acute Leukemias.- 6. Preleukemia and Myelodysplastic Disorders.- 7. Cytogenetic Changes in Chronic Lymphocytic Leukemia (CLL).- 8. Cytogenetic Aspects of Lymphoma.- 9. Diagnostic and Prognostic Aspects of Chromosome Changes in Leukemia and Lymphoma.- References.- Cytogenetics of Solid Tumors: Renal Cell Carcinoma, Malignant Melanoma, Retinoblastoma, and Wilms’ Tumor.- 1. Introduction.- 2. Materials and Procedures.- 3. Renal Cell Carcinoma (RCC).- 4. Malignant Melanoma (MM).- 5. Retinoblastoma (RB).- 6. Wilms’ Tumor (WT).- 7. Discussion.- 8. Concluding Remarks.- References.- Elucidation of a Normal Function for a Human Proto-Oncogene.- 1. Introduction.- 2. A Primate Sarcoma Virus with Novel Properties.- 3. Molecular Cloning of the Biologically Active SSV Genome.- 4. Molecular Organization of the SSV Genome.- 5. Detection and Localization of a Non-SSAV-Related Region of SSV.- 6. v-sis Is Cell Derived and Required for SSV Transforming Activity.- 7. Predicted Coding Sequence of the SSV Transforming Gene.- 8. Detection of the SSV Transforming Gene Product.- 9. p28sis Is Related to Human Platelet-Derived Growth Factor.- 10. Close Structural and Conformational Similarity Between the SSV Transforming Gene Product and Biologically Active PDGF.- 11. Anti-PDGF Serum Recognizes SSV Transforming Gene Products.- 12. The Human c-sis Locus.- 13. Mechanism of SSV Transformation.- References.- Detection of HSV-2 Genes and Gene Products in Cervical Neoplasia.- 1. Introduction.- 2. Etiologic Factors.- 3. Herpes Genitalis Infections.- 4. Pathologic Featuresof Cervical Neoplasia.- 5. Seroepidemiologic Studies Linking HSV-2 to Cervical Neoplasia.- 6. Herpes-Specific Antigens in Cervical Neoplasia.- 7. HSV Genetic Sequences in Cervical Neoplasia.- 8. Postulated Mechanisms of Oncogenesis for Cervical Neoplasia.- References.- Papillomaviruses in Anogenital Neoplasms.- 1. Introduction.- 2. Papillomavirus Properties.- 3. Evidence for the Association of HPV with Anogenital Neoplasia.- 4. Detection of HPV Structural Antigens.- 5. Detection of HPV DNA Sequences.- 6. Papillomaviruses and Cancer.- References.- Human Epstein-Barr Virus and Cancer.- 1. Introduction.- 2. EBV Virion, Antigens, and Genome.- 3. Oncogenicity of EBV.- 4. Ubiquity of EBV in Humans.- 5. Epstein-Barr Virus and Human Cancer.- 6. Protection Against EBV-Induced Oncogenesis.- 7. Summary.- References.- Hepatitis B Virus and Hepatocellular Carcinoma.- 1. Introduction.- 2. Structure and Biology of Hepatitis B Virus.- 3. Molecular Analyses of Hepatitis B Virus Infection and Hepatocellular Carcinoma.- 4. Presence of Hepatitis B Virus DNA in Nonhepatocytes.- 5. Presence, State, and Molecular Structure of Hepatitis B Viral DNA in Hepatocellular Carcinoma.- 6. Expression of Viral Genes in Hepatocellular Carcinoma.- 7. Molecular Mechanisms of Malignant Transformation of Hepatocytes.- 8. Epidemiology of Hepatocellular Carcinoma.- 9. Clinical Aspects of Hepatocellular Carcinoma.- 10. Summary and Conclusions.- References.- Kaposi’s Sarcoma: Acquired Immunodeficiency Syndrome (AIDS) and Associated Viruses.- 1. Introduction.- 2. Kaposi’s Sarcoma.- 3. Kaposi’s Sarcoma and AIDS.- 4. KS and HLA.- 5. KS and CMV.- 6. AIDS-Etiologic Agent.- 7. African KS and AIDS.- 8. Summary.- References.