The Histology of Borderline Cancer

1 A Philosophy of Cancer Diagnosis by Microscopy.- Series of Cases Analysed.- Rationale of Histopathological Diagnosis.- Validity of Histological Criteria of Malignancy.- Use of Clinical Data.- The Histopathological Audit.- 2 Lesions of the Breast.- Local Series.- Summarised Totals.- Case Data.- Commentary on Local Series.- General Commentary.- Dysplasia.- Lobular Carcinoma in Situ.- Intraduct Carcinoma.- Paget’s Disease of the Nipple.- Cystosarcoma Phyllodes.- Prognosis.- Conclusions.- 3 Lesions of the Thyroid Gland.- Local Series.- Summarised Totals.- Case Data.- Commentary on Local Series.- General Commentary.- Microfollicular Adenoma.- Papillary Carcinoma.- Multifocal Carcinoma.- Medullary Carcinoma.- Lymphoreticular Neoplasms.- Hyperthyroidism.- Cryptic Carcinoma.- Conclusions.- 4 Lesions of Lymph Nodes.- Local Series.- Case Data I: ? Hodgkin’s Disease.- Case Data II: ? Malignant Lymphoma Other than Hodgkin’s Disease.- Commentary on Local Series.- General Commentary.- Hodgkin’s Disease.- Non-Hodgkin’s Lymphomas.- Lesions that may Simulate ML.- Conclusions.- 5 Lesions of the Soft Tissues.- Local Series.- Summarised Totals.- Case Data.- Commentary on Local Series.- General Commentary.- Pseudo-sarcomatous Lesions.- Myxoma.- Mesenchymoma, Benign and Malignant.- Neoplasms of Fat.- Fasciitis (Pseudo-sarcomatous, Nodular).- Histiocytoma.- Juvenile Fibromatoses.- Desmoid Tumour.- Fibrosarcoma.- Granulation Tissue Sarcoma: Haematoma-sarcoma.- Granular Cell Myoblastoma.- Proliferative Myositis.- Myositis Ossificans.- Bony Neoplasms of Soft Tissue.- Synovial Overgrowths.- Epithelioid Sarcoma.- ‘Staging’ of Soft Tissue Sarcomas.- Conclusions.- 6 Lesions of Bone and Cartilage.- Local Series.- Summarised Totals.- Case Data.- Commentary on Local Series.- General Commentary.- Clinical Evidence vs Histological Evidence.- Inflammatory Patterns vs Neoplastic Patterns.- Chondroma vs Chondrosarcoma.- Callus vs Osteosarcoma vs Chondrosarcoma.- Predominantly Fibroblastic Lesions Containing Giant Cells.- Conclusions.- 7 Lesions of the Skin.- A: Epithelial Lesions Other than Melanocarcinoma.- Overgrowths of Stratified Squamous Epithelium.- Local Series.- General Commentary.- Basal Cell Carcinoma.- Extramammary Paget’s Disease (EMPD).- Conclusions.- B: The Problem of Mycosis Fungoides and Comparable Conditions.- Local Series.- General Commentary.- Lymphocytic Infiltrations of the Skin.- Other Pseudo-malignant Lesions.- Conclusions.- C: Melanocarcinoma.- Local Series.- Summarised Totals.- Case Data.- Commentary on Local Series.- General Commentary.- Classification.- Constituent Cells.- Lentigo Maligna.- Spitz Naevus.- Diagnosis by Frozen Section.- Trauma.- Lymphadenectomy.- Pregnancy.- Influence of Age.- Delay in Metastasis.- Conclusions.- 8 Lesions of the Digestive Tract.- Local Series.- Summarised Totals.- Case Data.- Commentary on Local Series.- General Commentary.- Oral Cavity.- Salivary Tissue.- Palate.- Pharynx.- Oesophagus.- Stomach.- Small Intestine.- Large Intestine.- Carcinoid Tumour.- Malignant Lymphoma and Pseudo-lymphoma.- Plasma Cell Lesions.- Pancreatic Biopsy.- Serosal Metaplasia.- Endometriosis.- Conclusions.- 9 Lesions of the Respiratory Tract.- Local Series.- Case Data.- General Commentary.- Nose and Nasopharynx.- Larynx.- Bronchus and Lung.- Conclusions.- 10 Lesions of the Female Genital Tract.- Local Series.- Case Data.- Commentary on Local Series.- General Commentary.- Vulva.- Cervix Uteri.- Endometrium, the Glandular Component.- Endometrium, the Stromal Component, and Myometrium.- Ovary.- Trophoblast.- Endometriosis.- Conclusions.- 11 Some Miscellaneous Lesions.- Case Data.- General Commentary.- Nervous System.- The Eye and Orbit.- Urinary Tract.- Bladder.- Vasculature.- Conclusions.- 12 General Assessment.- Comment in Summary.