Advances in Human Genetics 15

1 Chromosomal Abnormalities in Leukemia and Lymphoma: Clinical and Biological Significance.- Methods.- Chronic Myelogenous Leukemia (CML).- Acute Nonlymphocytic Leukemia (ANLL) de Novo.- Acute Nonlymphocytic Leukemia Induced by Treatment.- Acute Lymphocytic Leukemia (ALL).- Malignant Lymphoma (ML).- The Biological Significance of Consistent Chromosomal Abnormalities.- References.- 2 An Algorithm for Comparing Two-Dimensional Electrophoretic Gels, with Particular Reference to the Study of Mutation.- The Theory and Practice of Two-Dimensional Gels, with Particular Reference to the Study of Mutation.- The General Problem of Image Comparison.- A Set of Algorithms for Detecting Potential Mutational Events.- Validation of the Current Algorithm.- Improving the System: Necessary Developments in the Algorithm.- Improving the System: Necessary Developments in Two-Dimensional Gels.- Experimental Validation of This Approach.- Some Issues in Data Management.- Summary.- Recent Developments.- References.- 3 The Human Argininosuccinate Synthetase Locus and Citrullinemia.- Historical Aspects.- Biology of the Argininosuccinate Synthetase Locus.- Biochemistry of the Enzyme.- Cloning of Human Argininosuccinate Synthetase Gene.- Argininosuccinate Synthetase Pseudogenes.- Citrullinemia—Clinical Aspects.- Molecular Analysis in Citrullinemia.- Molecular and Genetic Analysis of Regulation.- Gene Transfer Using the Argininosuccinate Synthetase Locus.- Future Directions.- References.- 4 Molecular Genetics of the Human Major Histocompatibility Complex.- Characterization of the HLA Genes.- HLA Genes As Probes.- Conclusion.- References.- 5 Genetics of Human Alcohol and Aldehyde Dehydrogenases.- Alcohol Dehydrogenases.- Aldehyde Dehydrogenases.- References.- Addendum.