Vascular Complications of Diabetes (eBook)

Richard Donnelly MD PhD FRCP FRACP is Professor of Vascular Medicine at the University of Nottingham and Honorary Consultant Physician at the J. O'Neil Diabetic Centre, Derbyshire Royal Infirmary, Derby, UK

VASCULAR COMPLICATIONS OF DIABETES CURRENT ISSUES IN PATHOGENESIS AND TREATMENT SECOND EDITION 3
CONTENTS 5
List of contributors 7
Preface 8
SECTION I MICRO- AND MACROVASCULAR COMPLICATIONS OF DIABETES 9
Chapter 1 The public health impact of the diabetes epidemic 11
Chapter 2 Risk factors 21
Chapter 3 Diabetic nephropathy 31
Chapter 4 Coronary heart disease and diabetes 43
Chapter 5 Diabetes and cerebrovascular disease 53
Chapter 6 Erectile dysfunction 59
Chapter 7 Evidence-based interventions to prevent or retard vascular complications 67
SECTION II DIABETIC NEUROPATHIES 85
Chapter 8 Classification and clinical features of neuropathy 87
Chapter 9 Pathophysiology of diabetic neuropathy 93
Chapter 10 Epidemiology and natural history of DPN 99
Chapter 11 Detection/Screening/Assessment 105
Chapter 12 Foot ulceration and Charcot arthropathy 113
Chapter 13 Treatments options 121
Chapter 14 Management guidelines for diabetic peripheral neuropathy and foot ulceration 129
SECTION III DIABETIC RETINOPATHY AND ASSOCIATED OPHTHALMIC DISORDERS 135
Chapter 15 Diabetic retinopathy: epidemiology and risk factors 137
Chapter 16 Classification and diagnosis of diabetic retinopathy 147
Chapter 17 Diabetic maculopathy 159
Chapter 18 Proliferative diabetic retinopathy 171
Chapter 19 Non-retinal diabetic ocular complications 179
SECTION IV MECHANISMS OF HYPERGLYCAEMIA INDUCED VASCULAR DYSFUNCTION 185
Chapter 20 Pathophysiology and potential targets for therapeutic intervention 187
Chapter 21 Protein kinase C 197
Chapter 22 Protein kinase C activation and vascular permeability 205
Chapter 23 Role of protein kinase Cactivation in cardiovascular and renal complications of diabetes 213
Chapter 24 Experimental pharmacology using isoform-selective protein kinase Cinhibitors 221
Chapter 25 Clinical trials with ruboxistaurin 229
Index 234