Thymus (eBook)

Sir Gordon Ethelbert Ward Wolstenholme OBE FRCP was a British medical doctor, and the founding director of the Ciba Foundation. He was born in Sheffield, the son of a mechanical engineer, and educated at Repton School and Corpus Christi, Cambridge.

THE THYMUS: EXPERIMENTAL AND CLINICAL STUDIES 5
Contents 11
Chairman’s opening remarks 17
Cytological evidences of secretion in the thymus 19
Discussion 46
Embryogenesis of immune systems 55
Discussion 65
The origin and function of lymphocytes 74
Discussion 95
Differentiation and immunological competence of cloned cell populations of lymphoid origin 102
Discussion 115
The thymus in relation to immunological tolerance 121
Discussion 139
Traffic of lymphoid cells in the body* 147
The thymus in relation to the development of immunological capacity 169
Discussion 190
The development of the central and peripheral lymphoid tissue: ontogenetic and phylogenetic considerations 197
Discussion 223
The function of the thymus in tumour production by polyoma virus** 230
The nature and regulation of lymphopoiesis in the normal and neoplastic thymus 258
General Discussion 280
Parallel observations on the role of the thymus in leukaemogenesis, immunocompetence and lymphopoiesis 304
Interaction of occult leukaemogenic viruses with ionizing radiation and other external leukaemogenic agents in the induction 326
Discussion 340
Mast cells i n the mouse thymus 351
Discussion 357
Lymphocytes and antibodies i n relation t o malignant disease* 364
The influence of neonatal thymectomy and thymus grafting on spontaneous auto-immune disease i n mice 376
Thymic changes in NZB mice and hybrids 397
Discussion 406
lmmunocytes and immunoproliferative disorders 415
The thymus and human diseases with autoimmune concomitants with special reference to myasthenia gravis 432
Discussion 455
Histopathology of the human thymus 465
Discussion 480
The significance of auto-immune disease* 492
Group Discussion 510
Chairman’s closing remarks 536