Control of Glycogen Metabolism (eBook)

W. J. Whelan and Margaret P. Cameron are the authors of Control of Glycogen Metabolism, published by Wiley.

CONTROL OF GLYCOGEN METABOLISM 1
Preface 9
Contents 10
Chairman’s opening remarks 17
Basic Processes of Glycogen Metabolism 23
Structure of glycogen and its amylolytic degradation 23
Discussion 40
Physical characteristics of undegraded glycogen 45
Discussion 61
Intestinal hydrolysis and absorption of glycogen-derived oligosaccharides 70
Discussion 80
Rôle of uridine diphosphate glucose in the synthesis of glycogen 86
Discussion 99
Branching enzyme 105
Discussion 109
The structure of phosphorylases 112
Discussion 121
The influence of phosphorylase on the structure of glycogen 125
Discussion 133
The enzymic debranching of glycogen and the rôle of transferase 141
The rôle of oligo-l,4 -> 1,4-glucantransferase and amylo-1,6-glucosidase in the debranching of glycogen
The mechanism of action of amylo-1,6-gIucosidase 170
Discussion 182
Animal tissue y-amylase and its rôle in the metabolism of glycogen 195
Discussion 208
General discussion 212
Basic processes of glycogen metabolism 212
Control of Glycogen Metabolism 219
Interconversion reactions of muscle phosphorylases b and a 219
Regulation of glycolysis in skeletal muscle 230
Discussion 247
The cellular locatipn of adenyl cyclase and adenosine-3,5’-phosphate in Escherichia coli 252
Discussion 262
Biochemical effects of adrenaline on intestinal smooth muscle 266
Discussion 271
Regulation of glycogenolpis in muscle 273
Discussion 289
Insulin and the control of UDPG ?-glucan transglucosylase activity 292
Discussion 307
Possible indirect effects of adrenaline on glycogen metabolism 313
Discussion 316
Hexokinase and glucokinase 320
Discussion 322
Glycogen Storage Diseases 324
Clinical manifestations of glycogen storage diseases 324
Discussion 337
Glycogen storage disease, Type I 340
Discussion 352
Glycogen storage diseases, Types III, IV, and VI 355
Discussion 368
Glycogen storage disease, Type II 373
Discussion 383
Glycogen storage disease, Type V 386
Discussion 394
Glycogen synthetase deficiency 397
Discussion 404
Studies of storage disease glycogens 407
Discussion 413
General Discussions 414
Glycogen storage diseases 414
Diagram of glycogen synthesis and degradation 422
Enzyme nomenclature 434
Author index 437
Subject index 439