Regulation and Mode of Action of Thyroid Hormones, Volume 10 (eBook)

Sir Gordon Ethelbert Ward Wolstenholme OBE FRCP was a British medical doctor, and the founding director of the Ciba Foundation. He was born in Sheffield, the son of a mechanical engineer, and educated at Repton School and Corpus Christi, Cambridge.

CIBA FOUNDATION COLLOQUIA ON ENDOCRINOLOGY VOLUME 10 5
CONTENTS 9
Chairman's opening remarks 15
Hypothalamus-pituitary -thyroid relationships 17
Discussion 30
Contribution to the regulation of thyroid activity 37
Discussion 46
The influence of the central nervous system on the control of thyrotrophin secretion 50
Discussion 63
Pituitary cytology in relation to thyrotrophic hormone secretion 67
Discussion 73
Effects of hypophysectomy on organic iodine formation in rat thyroids 75
Discussion 92
Factors influencing the thyroidal iodide pump 99
Discussion 114
The "feed-back" hypothesis of the control of thyroid function 117
Discussion 136
General Discussion 141
Hormone synthesis in the iodine-deficient thyroid gland 144
Discussion 152
Enzymic aspects of thyronine metabolism and its iodinated derivatives 155
Discussion 173
The metabolism of thyroid hormones by kidney and the biological activity of the products 176
Discussion 186
On the presence of 3 : 5 : 3'-triiodothyroacetic acid and 3 : 3'-diiodothyronine in rat muscle and kidney after administration of 3 : 5 : 3'-triiodo-L-thyronine 190
Discussion 204
The distribution and metabolism of thyroid hormones 208
The deiodination of thyroid hormones in vitro 220
Discussion 232
General Discussion 236
Hepatic regulation of thyroxine metabolism 247
Discussion 255
Thyroid hormones at the peripheral tissue level: metabolism and mode of action 264
Discussion 280
Cellular actions of thyroxine and similar compounds 287
Discussion 300
Some observations on the clinical effects of triiodothyroacetic acid 304
Discussion 314
The influence of the thyroid gland upon immune responses of different species to bacterial infection 321
Discussion 327
General Discussion 332