Internal Secretions of the Pancreas, Volume 9 (eBook)

Sir Gordon Ethelbert Ward Wolstenholme OBE FRCP was a British medical doctor, and the founding director of the Ciba Foundation. He was born in Sheffield, the son of a mechanical engineer, and educated at Repton School and Corpus Christi, Cambridge.

CIBA FOUNDATION COLLOQUIA ON ENDOCRINOLOGY VOLUME 9 5
CONTENTS 9
Chairman's opening remarks 15
Morphological studies of the destruction of a-cells by chemical means 16
Discussion 27
Metabolic effects of a-cell destruction 36
Discussion 48
Pituitary growth hormone and blood insulin activity 57
Discussion 73
The control of the secretory activity of the islets of Langerhans 77
Discussion 96
The effects of hypophysectomy and of prolonged growth hormone administration on the pancreatic a-cells of the rat 99
Discussion 113
Fractionation of insulin 117
Discussion 131
The chemical structure of insulin 138
Discussion 147
A concept of the three-dimensional structure of insulin 150
A speculation on insulin 163
Discussion 171
Insulin and glucagon 177
Discussion 193
Chemical and biological characteristics of glucagon 197
Discussion 204
The action of glucagon on liver phosphorylase 209
Discussion 221
Inhibitory effect of glucagon on the insulin glucose uptake of the isolated diaphragm of the rat 224
Discussion 228
The hepatic action of insulin 233
Discussion 253
Some problems of permeability of tissue cells to sugars 257
The transport of glucose and other sugars across cell membranes and the effect of insulin 270
Discussion 290
Pancreatic islets and growth 296
Discussion 312
Chairman's closing remarks 317