Hormonal Influences in Water Metabolism, Volume 4 (eBook)

Sir Gordon Ethelbert Ward Wolstenholme OBE FRCP was a British medical doctor, and the founding director of the Ciba Foundation. He was born in Sheffield, the son of a mechanical engineer, and educated at Repton School and Corpus Christi, Cambridge.

CIBA FOUNDATION COLLOQUIA ON ENDOCRINOLOGY VOLUME IV 5
CONTENTS 9
Book I—ANTERIOR PITUITARY SECRETION 25
Foreword by the Chairman 26
Part I—Anatomy, Histology and Cytology 27
Cytochemical localization of the protein hormones of the anterior hypophysis 27
Discussion 47
Physiological meaning of the histological picture of the anterior hypophysis characteristic of castration, pregnancy and thyr 49
Discussion 60
Structural changes in the anterior pituitary, with spedal reference to the adrenal cortex 61
Discussion 77
Nerve fibres in the adenohypophysis under normal and experimental conditions 82
Discussion 99
Gomori-positive and Gomori-negative nerve fibres in the neurohypophysis and their physiological significance 101
Discussion 107
Comparative aspects of the hypophysis, especially of blood supply and innervation 110
Discussion 126
Part II—Control of Secretions of the Anterior Pituitary 129
The relationship of the hypothalamus to the pituitary secretion of ACTH 129
Discussion 144
Hypothalamic control of ACTH secretion by the pituitary gland 147
Hypothalamic control of the anterior pituitary gland 150
Functional hypophyseal grafts 159
Discussion 165
Studies on the control of ACTH release by means of hypo-physeal transplants 170
Discussion 182
The role of epinephrine in the secretion of the adrenal cortex 185
Neural control of secretion of ACTH 194
The role of adrenaline in the response of the adrenal cortex to stress of various kinds, including emotional stress 200
Discussion 206
Presumptive hypothalamic control of spontaneous ovulation 213
Discussion 227
The influence of certain adrenergic and cholinergic drugs on urinary gonadotrophin output in amenorrhaeic women 229
Discussion 234
The occurrence of histamine in cerebral regions related the hypophysis 236
Discussion 243
The influence of various steroids and steroid hormones on the hormonal activity of the anterior lobe of the pituitary glande 245
Discussion 251
The co-ordination of hypothalamic vegetative controls 253
Discussion 260
The influence of environmental changes on the pituitary 263
Studies with radioactively labelled anterior pituitary preparations 279
Discussion 291
Attempts at inhibition of anterior lobe secretion by p-hydroxypropiophenone 295
Discussion 302
Part III—Growth Hormone 305
The growth hormone and carbohydrate metabolism 305
Discussion 310
Part IV—Gonadotrophins 314
Ovarian periodicity in the absence of cyclic structures 314
Discussion 318
Inter-relations of gonadotrophic and gonadal hormones in the regulation of testicular functions 321
Discussion 331
Gonadotrophin excretion in man 333
Discussion 341
Part V—Thyrotrophic Hormone 344
Factors which influence the physiological reactions of the thyroid-stimulating hormone of the pituitary 344
Discussion 362
Penetration of labelled thyroxine into the hypophysis: recent findings 363
Discussion 367
The mechanism of experimental exophthalmos caused by pituitary extracts 368
Discussion 377
Part VI—Adrenocorticotrophic Hormone 381
On the bioassay of adrenocorticotrophic hormone 381
Discussion 399
Ovarian response to ACTH 401
Discussion 408
Experiences in the administration of ACTH to infants 410
Discussion 415
Some remarks on the pathophysiology and therapy the adrenogenital syndrome 417
Discussion 424
A proposed mechanism for the synthesis of steroids the adrenal cortex 426
Discussion 433
Part VII—Lactogenic and Mammogenic Hormones 435
Some aspects of the physiology of the anterior-pituitary lactogenic hormone 435
Discussion 446
Interaction between prolactin and progesterone in the regulation of the secretory processes in the mammary gland 449
Discussion 454
Hypophyseal and ovarian hormones in the regulation of the mammary glands 456
Discussion 464