Steroid Hormones and Tumour Growth, Volume 1 (eBook)

Sir Gordon Ethelbert Ward Wolstenholme OBE FRCP was a British medical doctor, and the founding director of the Ciba Foundation. He was born in Sheffield, the son of a mechanical engineer, and educated at Repton School and Corpus Christi, Cambridge.

CIBA FOUNDATION COLLOQUIA ON ENDOCRINOLOGY VOLUME I 5
CONTENTS 13
Book II—STEROID HORMONES AND ENZYMES 25
Assay, activity and purification of b-glucuronidase 27
Discussion 30
The nature, properties and function of b-glucuronidase 33
Discussion 38
On the mechanism of synthesis of conjugated glucuronides 41
Discussion 44
The metabolism and excretion of synthetic estrogens, with special reference to the formation of the glycuronldes 47
Discussion 51
The effects of hormones on b-glucuronidase activity: mouse tissues interaction of b-glucuronidase and oestriol glucuronide
Discussion 58
Enzymes in the corpora lutea of the rat during pregnancy and lactation. Enzymes in the placentoma of the rat 61
Discussion 64
The effects on enzymes of androgens and growth hormone 69
Discussion 74
Comparison of b-glucuronidase activity in tissues of foetal, new-born, and infant animals with those of the mother (mouse, d 77
Discussion 78
Relation of glucuronidsse to action of gonadal hormones 79
Discussion 80
The growth inhibiting action of cancer producing substances in relation to hormonal control of protein and carbohydrate met 82
Discussion 85
The effects on enzymes of adrenal cortex, diet, estrogens, and experimental diabetes 87
Discussion 93
Tiseue arginase in relation to the adrenal cortex and diabetes 97
Discussion 100
Succinic dehydrogenase and anaerobic glycolysis in the livers of diabetic lactating rats 103
Discussion 103
Closing Remarks 106