Mammary Tumor Cell Cycle, Differentiation, and Metastasis

A. Mouse models of mammary development and tumorigenesis.- 1. Programmed cell death and mammary neoplasia.- 2. Tissue reconstitution or transgenic mammary gland technique for modeling breast cancer development.- 3. Preneoplasia in mammary tumorigenesis.- 4. Transgenic models of breast cancer metastasis.- B. Human breast cancer: Receptors, signaling, and the cell cycle.- 5. Protein kinase C and breast cancer.- 6. Protein tyrosine phosphatases: Cellular regulators of human breast cancer?.- 7. Role of the nuclear matrix in breast cancer.- 8. Cyclins and breast cancer.- 9. Nuclear oncogenes in breast cancer.- 10. Antiprogestin-progestin interactions.- 11. Antiestrogen-estrogen receptor interactions.- C. Human breast cancer: Invastion, Metastasis, Angiogenesis, and Immunology.- 12. Differentiation antigens in stromal and epithelial cells of the breast.- 13. Models of progression spanning preneoplasia and metastasis: The human MCF-10A neo T.TGN series and a panel of mouse mammary tumor subpopulations.- 14. Angiogenesis in breast cancer.- 15. Cell motility in breast cancer.- 16. Cathepsins D and B in breast cancer.- 17. Stromelysin-3 and other stromelysins in breast cancer: Importance of epithelial-stromal interactions during tumor progression.- 18. Endothelins in breast cancer.- 19. Breast cancer immunology.