Advances in Parasitology (eBook)

Front Cover 1
Advances in Parasitology, Volume 42 4
Copyright Page 5
Contents 12
Contributors to Volume 42 6
Preface 8
Chapter 1. The Southern Cone Initiative Against Chagas Disease 16
1. Introduction 17
2. Epidemiology of Chagas Disease 18
3. Chagas Disease in the Southern Cone 20
4. Experience in Chagas Disease Vector Control 22
5. Development of the Southern Cone Programme 24
6. Implementation of the Southern Cone Programme 27
7. Results 29
8. Reinfestation of Treated Houses 34
9. Political Developments 36
Acknowledgements 37
References 37
Chapter 2. Phytomonas and Other Trypanosomatid Parasites of Plants and Fruit 44
1. Introduction 46
2. Early Nomenclature 47
3. Morphology 49
4. Occurrence and World Distribution 55
5. Culture and Nutrition 62
6. Biochemistry and Molecular Biology 72
7. Taxonomy and Identification 83
8. Phylogeny 90
9. Pathogenesis 91
10. Transmission 100
11. Reservoirs 102
12. Diagnosis 103
13. Treatment and Prophylaxis 105
Appendix 106
References 108
Chapter 3. Paragonimiasis and the Genus Paragonimus 128
1. Introduction 129
2. Morphology and Taxonomy 130
3. Life Cycles of Paragonimus Species 136
4. Strains, Species and Genetics 143
5. The Species of Paragonimus 147
6. Paragonimus Species as Parasites of Humans and Domestic Animals 187
7. Biochemistry and Physiology 197
8. Paragonimus Species as Model Organisms 199
Acknowledgements 200
References 200
Chapter 4. Immunology and Biochemistry of Hymenolepis diminuta 238
1. Introduction 239
2. The Nature of Immunity to Hymenolepis diminuta in the Rat 241
3. Metabolism 254
4. Strain Variation and the Crowding Effect 270
5. Conclusion 276
Acknowledgements 277
References 277
Chapter 5. Control Strategies for Human Intestinal Nematode Infections 292
1. Introduction 293
2. Public Health Relevance of Intestinal Helminths: Recent Estimates 294
3. Infection Control or Disease Control? 297
4. Strategies for Control: an Update 301
5. Planning an Intestinal Helminth Control Programme 322
6. Intestinal Helminth Control Programmes: Country Experience 325
7. Cost-effectiveness and Sustainability 337
8. Drug Resistance 340
9. Future Directions 342
References 343
Chapter 6. DNA Vaccines: Technology and Application as Anti-parasite and Anti-microbial Agents 358
1. Introduction 359
2. Plasmid Vectors Available for DNAVaccine Use 362
3. RNA Vaccines 363
4. Methods of Delivery 364
5. Immune Responses Generated by Nucleic Acid 371
6. Use of DNAVaccines Against Infectious and Parasitic Diseases 385
7. Nucleic Acids as Anti-cancer Vaccines 401
8. DNA Vaccines in Gene Therapy 402
9. Safety Issues 402
10. Final Comments 403
Acknowledgements 404
References 405
Index 426