Advances in Cancer Research (eBook)

Cover 1
Contents 6
Contributors to Volume 74 8
Chapter 1. Key Effectors of Signal Transduction and G1 Progression 10
I. Introduction 10
II. The G1 Phase of the Mammalian Cell Cycle 12
III. Signal Transduction and G1 Progression 14
IV. The RAS/ERK Pathway and the Cell Cycle 14
V. RAS, D-Type Cyclins, and RB Connections 18
VI. Cycling with MYC 20
VII. Interplay between MYC and Cyclin D1 22
VIII. Signaling and Cell Cycle Roles of the SRC Family of Kinases 23
IX. Concluding Remarks 24
References 25
Chapter 2. p53 in Tumor Progression: Life, Death, and Everything 34
I. Introduction 34
II. Biochemical Activities of p53 35
III. p53 and Cell Cycle Control 36
IV. p53 and Apoptosis 38
V. p53 and Tumor Progression 46
References 51
Chapter 3. Signal Transduction through MAP Kinase Cascades 58
I. The MAP Kinase (MAPK) Module 58
II. Mammalian MAPK Pathways 59
III. Regulation of MAPK Pathways by Protein Phosphatases 84
IV. Cellular Substrates of MAP Kinases 90
V. Responses to MAPK Pathways: Growth and Differentiation 100
VI. Yeast MAPK Pathways 109
VII. Intracellular Targeting and Spatial Regulation of MAPK Pathway Components 120
VIII. Future Directions 122
References 123
Chapter 4. FHIT in Human Cancer 150
I. Introduction 150
II. Cloning and Structural Features of the FHIT Gene 153
III. The Fhit Protein and Its Biochemical Properties 155
IV. FHIT Abnormalities in Human Cancer 156
V. Conclusions and Perspectives 167
References 168
Chapter 5. Phosphoinositide 4- and 5-Kinases and the Cellular Roles of Phosphatidylinositol 4,5-Bisphosphate 176
I. Introduction 176
II. Receptor-Linked Phosphoinositide Metabolism 183
III. Phosphoinositides and the Cytoskeleton 196
IV. Vesicle Biogenesis and Trafficking 204
V. Roles in Cancer, Summary, and Prospects 215
References 217
Index 226