Advances in Cancer Research (eBook)
328 Seiten
Elsevier Science (Verlag)
978-0-08-056249-0 (ISBN)
Advances in Cancer Research is a biannual publication that includes timely reviews on the most cutting-edge issues in cancer research. Topics covered in Volume 67 include a developmental model of progenitor cell oncogenesis based on a description of transcriptional control; pathways of chromosome alteration in human epithelial cancers, using colorectal, breast, lung, and endometrial cancers as examples; the genetics of murine lung tumors; the molecular pathogenesis of AIDS-related lymphomas; HLA class I antigens in human tumors, focusing on abnormal MHC expression detected in human tumors and the biological role these alterations may have in tumor development; a summary of the information obtained by the molecular characterization of EBV diversity and discussion of its relevance for viral epidemiology, transmission, and pathogenesis. There are two reviews discussing angiogenesis: the first focuses on the role of scatter factor and the second, the VEGF-FH receptor system. The "e;Foundations in Cancer Research"e; article by Alfred G. Knudson is a personal account of his career studying mutation and cancer. - A "e;Foundations in Cancer Research"e; article by Alfred G. Knudson, a personal account of his career studying mutation and cancer- A developmental model of progenitor cell oncogenesis based on a disruption of transcriptional control- Pathways of chromosome alteration in human epithelial cancers, using colorectal, breast, lung, and endometrial cancers as examples- A review of the genetics of murine lung tumors- Molecular pathogenesis of AIDS-related lymphomas- HLA class I antigens in human tumors, focusing on abnormal MHC expression detected in human tumors and the biological role these alterations may have in tumor development- A summary of the information obtained by the molecular characterization of EBV diversity and discussion of its relevance for viral epidemiology, transmission, and pathogenesis- The role of scatter factor in angiogenesis- The role of the VEGF-FH receptor system in normal and tumor angiogenesis
Cover 1
Contents 6
Contributers to Volume 67 10
Chapter 1. Foundation in Cancer Research Mutation and Cancer: A Personal Odyssey 12
I. Viruses, Somatic Mutations, and Cancer 12
II. Human Cancer Genes 18
III. The Emergence of Antioncogenes 23
IV. Conclusions 29
References 30
Chapter 2. Oncogenic Role of MasterŽ Transcription Factors in Human Leukemias and Sarcomas: A Developmental Model 36
I. Introduction 36
II. Transcriptional Control Genes Altered by Chromosomal Rearrangements 37
III. Oncogenic Transription Factors and the Developmental Regulatory Proteins of Drosophila 54
IV. Summary and Future Directions 61
References 63
Chapter 3. Pathways of Chromosome Alteration in Human Epithelial Cancers 70
I. Introduction 70
II. Colorectal Adenocarcinoma 72
III. Other Epithelial Tumors 79
IV. Microsatellite Instability in Epithelial Tumors 85
V. Concluding 88
References 89
Chapter 4. Genetics of Murine Lung Tumors 94
I. Historical Aspects 94
II. Comparative Aspects 95
III. Genetic Linkage Studies 106
IV. Transgenic Models of Lung Tumorigenesis 110
V. Candidate Lung Tumor Susceptibility Genes 111
VI. Genetics of Lung Tumors, Human 113
VII. Conclusions and Perspectives 116
References 117
Chapter 5. Molecular Pathogenesis of AIDS-Related Lymphomas 124
I. Epidemiology of AlDS-Related Lymphomas 124
II. Clinicopathologic Spectrum of AIDS-Related Lymphomas 126
III. Natural History of AIDS-Related Lymphomas 129
IV. Host Factors Contributing to AIDS-Related Lymphoma Development 131
V. Role of Viral Infection in AlDS-Related Lymphomagenesis 137
VII. Genetic Lesions Involved in AIDS-Related Lymphomas 143
VII. Conclusions: Distinct Pathogenetic Pathways in the Development of AIDS-Related Lymphomas 150
References 154
Chapter 6. HLA Class I Antigens in Human Tumors 166
I. Introduction 166
II. HLA Class I Antigen Expression in Normal Tissues 168
III. Role of MHC in T and NK Cell Recognition 177
IV. HLA and Tumor Antigens 181
V. Alterations of HLA Class I Expression in Human Tumors 182
VI. Clinical Implications 195
VII. Conclusions 195
References 196
Chapter 7. Molecular Epidemiology of Epstein–Barr Virus Infection 208
I. Introduction 208
II. EBV Genome and Gene Expression 211
III. EBV Typing at the DNA Level (Genotyping) 215
IV. EBV Typing at the Protein Level (Ebnotyping) 237
V. Differential Recognition of EBV Genotypes by the Immune System 248
VI. Final Conclusions: Implications for the Biology of EBV Infection 252
References 257
Chapter 8. Scatter Factor and Angiogenesis 268
I. Introduction: Scatter Factor (Hepatocyte Growth Factor) and the c-met Receptor 268
II. SF Biologic Actions on Blood Vessel Wall Cells in Vitro and in Vivo 270
III. SF as a Potential Tumor Angiogenesis Factor 277
IV. Role of SF in Angiogenesis: Hypotheses and Future Directions 284
V. Summary and Conclusions 288
References 289
Chapter 9. Role of VEGF-Flt Receptor System in Normal and Tumor Angiogenesis 294
I. Introduction 294
II. Structure and Functions of VEGF/VPF 296
III. Fit Receptor Gene Family: The Major Receptors for VEGF 309
IV. Regulation of Tumor Growth by the Suppression of VEGF-Flt Receptor System 322
References 324
Index 330
| Erscheint lt. Verlag | 22.11.1995 |
|---|---|
| Sprache | englisch |
| Themenwelt | Sachbuch/Ratgeber |
| Medizin / Pharmazie ► Allgemeines / Lexika | |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Mikrobiologie / Infektologie / Reisemedizin | |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Onkologie | |
| Studium ► Querschnittsbereiche ► Infektiologie / Immunologie | |
| Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
| Technik | |
| ISBN-10 | 0-08-056249-3 / 0080562493 |
| ISBN-13 | 978-0-08-056249-0 / 9780080562490 |
| Haben Sie eine Frage zum Produkt? |
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