Advances in Cancer Research (eBook)

Cover 1
Contents 6
Contributors to Volume 64 10
Chapter 1. Interactions between Papillomavirus Proteins and Tumor Suppressor Gene Products 12
I. Introduction 12
II. Human Papillomaviruses 13
III. Regulation of Cell Growth 16
IV. Viral/Host Protein Interactions 18
V. HPV Oncoproteins„Tools and Tarrets 29
References 30
Chapter 2.The Retinoblastoma Tumor Suppressor Protein 36
I. Overview 36
II. Mutation of Rb-1 in Tumors 37
III. Growth-Inhibitory Activity of RB 41
IV. Cell Cycle-Regulated Phosphorylation of RB 43
V. Protein-Binding Function of RB 59
VI. Regulation of RB Function by Phosphorylation 81
VII. Future Prospects 86
References 89
Chapter 3. SH2 and SH3 Domains in Signal Transduction 98
I. Protein Tyrosine Kinases and Their Targets 98
II. SH2 Domains 101
III. SH3 and PH Domains 109
IV. Coupling Tyrosine Kinases to Ras 111
V. SH2-Containing Phosphotyrosine Pliosphatases and the Genetics of Signal Transduction 115
References 116
Chapter 4. Activation of the Src Family of Tyrosine Kinases in Mammary Tumorigenesis 122
I. Introduction 122
II. Src Family of Protein Tyrosine Kinases 123
III. Elevation of c-Src Kinase Activity in Primary Mammary Tumors and Tumor-Derived Cell Lines 128
IV.Transgenic Mouse Models for Testing the Role of Src Family in Mammary Tumorigenesis 128
V. Future Prospects 131
References 131
Chapter 5. Oncogenic Properties of the Middle T Antigens of Polyomaviruses 136
I. Introduction 136
II. Consequences of PymT Expression in Vivo 144
III. Expression of the Hamster Polyomavirus Middle T Arlcigen in Vivo 159
IV. Analysis of PyniT-Transformed Endothelial Cells 160
V. Outlook 164
References 165
Chapter 6. Selective Involvement of Protein Kinase C Isozymes in Differentiation and Neoplastic Transformation 170
I. Introduction 171
II. PKC Isoforms Involved in Differentiation 187
III. Involvement of PKC Isoforms in Tumorigenesis 198
IV. Conclusions 207
References 209
Chapter 7. Fc. Receptors in Malignancies: Friends or Enemies? 222
I. Introduction 222
II. Structural Features of Fc.Rs 223
III. Ligand Binding and Fc.R Binding Sites 226
IV. Functions Mediated by Membrane-Bound Fc.Rs 228
V. Signal Transduction Mediated by Fc.Rs 230
VI. Expression of Fc.Rs 232
VII. Soluble Fc. Receptors 236
VIII. Mechanisms of sFc.R (IgG-BF) Production 238
IX. Regulatory Role of Membrane-Bound and Soluble Fc.Rs 241
X. Expression of FcRs on Tumor Cells 244
XI. sFcRs in Malignancies 246
XII. Biological Role of FcR-Mediated Functions in Malignancies 247
XIII. Conclusions 248
References 249
Chapter 8. Dissecting Molecular Carcinogenesis: Development of Transgenic Mouse Models by Epidermal Gene Targeting 258
I. Introduction 258
II. Development of Single Transgenic Genotypes 261
III. Development of Multiple Transgenic Genotypes 285
IV. Development of a Rapid Screening System for Tumor Promoters and Chemical Carcinogenesis 297
V. Summary and Future Prospects 299
References 301
Index 308