Advances in Cancer Research (eBook)

Cover 1
Contents 6
Contributors to Volume 65 10
Preface 12
Chapter 1. Genetics in the Thirties 14
I. Introduction 14
II. Genetics in the 1930s 15
III. Viewpoints and Paradigms in the 1930s 23
IV. Conclusion 27
References 28
Chapter 2. Historical Origins of Current Concepts of Carcinogenesis 30
I. Introduction 31
II. Exogenous Sources of Cancer 36
III. Mutation and Cancer 41
IV. Chemical Carcinogenesis: Early History 52
V. Mode of Action of Carcinogenic Polycyclic Aromatic Hydrocarbons„Early Historical Development 57
VI. The Scope of Chemical Carcinogenesis Broadens„DNA as an in Vivo Receptor 62
VII. The Advent of Mutational Spectra: Attempts to Correlate Carcinogen„DNA Reactions and Carcinogenic Genetic Changes at the Molecular Level 88
VIII. Summary and Conclusions 105
References 110
Chapter 3. From the Melanocyte to Melanoma to Tumor Biology 126
I. An Introduction to an Essay on the Nature of Cancer 126
II. The Only Research Plan. The Present: Studies of Tumor Biology in Maine, at the Beth Israel Hospital, and at Harvard 128
III. The Melanocyte. The Years at Tulane University 130
IV. The Biologic Forms of Primary Cutaneous Melanoma and Levels of Invasion. The Melanoma Studies at the Massachusetts General Hospital, Harvard, and the Establishment of the First Pigmented Lesion Clinic 134
V. Tumor Progression, the Dysplastic Nevus, and the Precursor State of Neoplasia. The Years in Philadelphia: Temple University and the Pigmented Lesion Group of the University of Pennsylvania 136
VI. Maine, the Beth Israel Hospital, Harvard Medical School, and Pathology Services, Inc. Back to the Future 144
References 151
Chapter 4. The Origins of the Small DNA Tumor Viruses 154
I. Introduction 154
II. The Viruses of Monkey Kidney Cells 160
III. The Origins of the DNA Tumor Viruses 161
IV. The Molecular Biology of the DNA Tumor Viruses 169
V. Conclusions 176
References 177
Chapter 5. Retroviruses and Wild Mice: An Historical and Personal Perspective 182
I. Introduction 182
II. Trapping of Wild Mice and Establishment of Aging Population in the Laboratory 186
III. Spontaneous Cancer, Lymphoma, Motor Neuron Disease, and Type C Retrovirus (MuLV) Infection in Aging Wild Mice 188
IV. Pathogenesis of Lymphomas 196
V. Pathogenesis of MuLV Neurologic Disease 197
VI. Nongenetic Control of Type C Virus and Associated Diseases in Wild Mice 200
VII. Genetic Control of type C Virus in Wild Mice by the Introduction of the Fv1b MuLV-Resistance Allele from Inbred Mice 201
VIII. Genetic Control of Type C Virus in Wild Mice by Natural Segregation of the Fv-4 Ecotropic MuLV-Resistance Allele 201
IX. Type B Mammary Tumor Viruses in Wild Mice 204
X. Lessons Learned 205
References 210
Chapter 6. Sol Spiegelman 216
Chapter 7. Growth Dysregulation in Cancer Cells 226
I. Introduction 226
II. College and Graduate Training 227
III. Cancer Research in 1950 228
IV. Regulatory Processes 228
V. Regulations in Higher Organisms 230
VI. Cancer and the Cell Surface 231
VII. The Restriction Point Hypothesis 231
VIII. A Short-Lived Regulatory Protein 232
IX. Transcription from the Promoter Region of the Mouse Thymidine Kinase (TK) Gene 233
X. Yi Complexes 234
XI. Cyclin E Is a Candidate R-Point Protein 235
XII. Cyclin Changes in Breast Cells 237
XIII. Breast Cancer in Vivo 239
XIV. Future Problems 239
References 240
Index 242