Annual Reports in Medicinal Chemistry (eBook)

Front Cover 1
Annual Reports in Medicinal Chemistry, Volume 24 4
Copyright Page 5
Contents 6
Contributors 10
Preface 12
Section I: CNS Agents 14
Chapter 1. Antipsychotic Agents 14
Chapter 2. Antianxiety Agents and Anticonvulsants 24
Chapter 3. Antidepressant Agents 34
Chapter 4. Central Muscarinic Ligands and Receptors 44
Chapter 5. Recent Advances in Excitatory Amino Acid Research 54
Section II: Cardiopulmonary and Vascular Agents 64
Chapter 6. Antihypertensive Agents 64
Chapter 7. Pulmonary and Antiallergy Agents 74
Chapter 8. Novel Applications of Leucotriene Intervention 84
Chapter 9. PAF Antagonists 94
Chapter 10. Potassium Channel Openers: New Biological Probes 104
Section III: Chemotherapeutic Agents 114
Chapter 11. Antibacterial Antibiotics 114
Chapter 12. Recent Advances in Antifungal Agents 124
Chapter 13. New Approaches to Antitumor Therapy 134
Chapter 14. Antiviral Agents 142
Chapter 15. Transport of Antibiotics into Bacteria 152
Section IV: Endocrinology, Immunology and Metabolic Disorders 160
Chapter 16. Treatment of Hypercholesterolemia 160
Chapter 17. Recent Advances in the Design and Evaluation of Inhibitors of Phospholipase A2 170
Chapter 18. Recent Advances in the Treatment of Inflammatory Bowel Disease 180
Chapter 19. Advances in Dermatology 190
Chapter 20. Pathogenesis and Treatment of Alopecias 200
Chapter 21. New Horizons in the Treatment of Proliferative Prostatic Disease 210
Section V: Topics in Biology 220
Chapter 22. Transgenic Animals and Evaluation of Therapeutics 220
Chapter 23. Second Generation Recombinant Therapeutic Proteins 226
Chapter 24. Exogenous Growth Factors in Dermal Wound Healing 236
Chapter 25. Regulation of Neutrophil Chemotaxis 246
Section VI: Topics in Chemistry and Drug Design 256
Chapter 26. Approaches to the Discovery of Non-Peptide Ligands for Peptide Receptors and Peptidases 256
Chapter 27. Recent Developments in the Mass Spectrometry of Peptides and Proteins 266
Chapter 28. Contrast Media for Magnetic Resonance Imaging 278
Chapter 29. New Directions in Positron Emission Tomography 290
Chapter 30. Polyamine Spider Toxins: Unique Pharmacological Tools 300
Section VII: Trends and Perspectives 308
Chapter 31. To Market, To Market—1988 308
COMPOUND NAME, CODE NUMBER AND SUBJECT INDEX 330
CUMULATIVE CHAPTER TITLES KEYWORD INDEX, VOLUMES 1—24 340
CUMULATIVE CONTRIBUTOR INDEX, VOLUMES 1—24 350
CUMULATIVE NCE INTRODUCTION INDEX, 1983—1988 364
CUMULATIVE NCE INTRODUCTION INDEX, 1983—1988, BY INDICATION 370