Annual Reports in Medicinal Chemistry (eBook)

Front Cover 1
Annual Reports in Medicinal Chemistry, Volume 18 4
Copyright Page 5
Contents 6
Contributors 3
Preface 12
SECTION I: CNS AGENTS 14
Chapter 1. Adenosine as a Neuromodulator in the Mammalian Central Nervous System 14
Chapter 2. Anti-Anxiety Agents, Anticonvulsants, & Sedative Hypnotics
Chapter 3. Antipsychotic Agents and Dopamine Agonists 34
Chapter 4. Cholecystokinin and Substance P in the Central Nervous System 44
Chapter 5. Antidepressants 54
Chapter 6. Analgesics, Opioids, and Opioid Receptors 64
SECTION II: PHARMACODYNAMIC AGENTS 74
Chapter 7. Pulmonary and Antiallergy Agents 74
Chapter 8. Antihypertensive Agents 82
Chapter 9. Calcium Antagonists–New Opportunities 92
Chapter 10. Agents for the Treatment of Peptic Ulcer Disease 102
Chapter 11. Prolonged Ventricular Repolarisation–A Prevention of Severe Arrhythmias? 112
SECTION III: CHEMOTHERAPEUTIC AGENTS 122
Chapter 12. Antibacterial Agents 122
Chapter 13. Bacterial Penicillin-Binding Proteins 132
Chapter 14. Antineoplastic Agents 142
Chapter 15. Antiviral Agents 152
Chapter 16. Immunotherapy of Infectious Diseases 162
SECTION IV: METABOLIC DISEASES AND ENDOCRINE FUNCTION 174
Chapter 17. Progress in Atherosclerosis Therapy: Hypolipidemic Agents 174
Chapter 18. Disease Modifying Anti-Rheumatic Drugs 184
Chapter 19. Pharmacological Developments in Dermatology 194
Chapter 20. Mechanism of Action of Insulin, Glucagon, and Somatostatin 206
Chapter 21. Structure - Activity Relationships of Calmodulin Antagonists 216
SECTION V: TOPICS IN BIOLOGY 226
Chapter 22. Tyrosine-Specific Protein Kinases 226
Chapter 23. Oncogenes 238
Chapter 24. In Vitro Mutagenesis: Powerful New Techniques for Studying Structure – Function Relationships in Proteins 250
Chapter 25. Early Biochemical Events Leading to Mast Cell and Basophil Degranulation 260
Chapter 26. Plasminogen Activators 270
Chapter 27. Natural Killer Cells: Role in Cell-Mediated Immunity 278
SECTION VI: TOPICS IN CHEMISTRY AND DRUG DESIGN 288
Chapter 28. Recent Advances in Drug Delivery System Technology 288
Chapter 29. Enzyme Immunoassay 298
Chapter 30. Progress in the Development of Radioimaging Agents 306
Chapter 31. Mathematical Models for Toxicity Evaluation 316
Chapter 32. Applications of Recombinant DNA Technology of Interest to Medicinal Chemists 320
COMPOUND NAME AND CODE NUMBER INDEX 330
CUMULATIVE CHAPTER TITLES KEYWORD INDEX 338
CUMULATIVE AUTHOR INDEX 353