Advances in Heterocyclic Chemistry (eBook)

Front Cover 1
Advances in Heterocyclic Chemistry, Volume 38 4
Copyright Page 5
Contents 6
Contributors 8
Preface 10
Chapter 1. Recent Advances in the Chemistry of Dihydroazines 12
I. Introduction 14
II. Scope and Limitations 17
III. General Overview of Dihydroazine Chemistry 17
IV. Dihydropyridazines 34
V. Dihydropyrimidines 56
VI. Dihydro-1,2,3-triazines 93
VII. Dihydro-1,2,4-triazines 94
VIII. Dihydro-1,3,5-triazines 102
IX. Conclusions 113
Chapter 2. Recent Advances in the Chemistry of Benzisothiazoles and Other Polycyclic Isothiazoles 116
I. Introduction 117
II. 1,2-Benzisothiazoles 118
III. 1,2-Benzisothiazolin-3(2H)-one 1,1-Dioxide (Saccharin) and Derivatives 127
IV. 2,1-Benzisothiazoles 133
V. Other lsothiazole Systems 141
VI. Selenium and Tellurium Analogues 143
Chapter 3. 1,4-Benzothiazines, Dihydro- 1,4-benzothiazines, and Related Compounds 146
I. Introduction 146
II. Natural Occurrence 149
III. Pharmacology of 1,4-Benzothiazines and Their Derivatives 153
IV. Agricultural Uses 156
V. Industrial Uses 157
VI. Synthesis 157
VII. Reactions of 1,4-Benzothiazines 178
Chapter 4. The Chemistry of Hydantoins 188
I. Introduction 189
II. Methods of Synthesis 189
III. Physicochemical Studies on Hydantoins 214
IV. Reactivity of Hydantoins and Their Derivatives 220
V. Uses and Applications 235
Chapter 5. Recent Progress in Barbituric Acid Chemistry 240
I. Introduction 240
II. Physicochemical Properties of Barbiturates 242
III. Reactivity of Barbiturates 274
IV. Analytical Methods for Barbiturates 299
V.Correlation Analysis in Barbituric Acid Chemistry 303
VI. Closing Remarks 306
VII. Addendum 308
Chapter 6. Heterocyclic ß-Enamino Esters, Versatile Synthons in Heterocyclic Synthesis 310
I. Introduction 311
II. Synthetic Approaches 312
III. Structure and Spectral Properties 320
IV. General Considerations of Chemical Reactivity 327
V. Electrophilic Attacks on the 2-Amino Group (or the Carbon-3 Atom). Synthesis of Polynuclear Heterocyclic Systems 329
VI. Nucleophilic Attacks of Amines and Diamines 354
VII. Cycloadditions and Reactions with Acetylenic Esters 358
VIII. 2-(Triphenylphosphorylidenamino) Esters. The Cycloaddition-Ring Enlargement Sequence 362
IX. Photochemistry 366
X. Heterocyclic ß-Enamino Nitriles 368
XI. Conclusion and Outlook 378
Cumulative Index of Titles 380