Advances in Heterocyclic Chemistry (eBook)

Front Cover 1
Advances in Heterocyclic Chemistry, Volume 14 4
Copyright Page 5
Contents 6
Contributors 8
Preface 10
Chapter 1. Recent Advances in the Chemistry of Mononuclear Isothiazoles 12
I. Synthesis of Mononuclear Isothiazoles 13
II. The Physiochemical Properties of Isothiazoles 25
III. The Chemical Properties of Isothiazoles 27
IV. Reactions Involving Cleavage of the Isothiazole Ring 45
V. Photochemical Reactions of Isothiazoles 48
VI. Biologically Active Isothiazoles 48
Chapter 2. Benzisothiazoles 54
I. Introduction 54
II. 1,2-Benzisothiazoles 55
III. 2,1-Benzisothiazoles 74
IV. Selenium and Tellurium Analogs 87
V. Tables 87
Chapter 3. Recent Advances in Pyrazine Chemistry 110
I. Introduction 110
II. Physical and Spectroscopic Properties 116
III. General Synthetic Methods 123
IV. General Chemical Properties 133
V. Substituted Pyrazines 138
VI. Reduced Pyrazines 193
VII. Pyrazine N-Oxides 203
VIII. Biological Activity 219
Chapter 4. Heterocycles by Ring Closure of Ortho-Substituted t-Anilines (the t-Amino Effect) 222
I. Introduction 222
II. Interactions of the Ortho Substituent with the Nitrogen in t-Anilines 223
III. Interactions of the Ortho Substituent with the a-Methylene Group in t-Anilines 236
Chapter 5. I,2-Dihydroisoquinolines 290
I. Introduction 290
II. Formation 291
III. Stability 300
IV. Detection and Estimation 305
V. Reactions 305
Chapter 6. Benzo[c] thiophenes 342
I. Introduction 342
II. Theoretical Aspects 344
III. Hydrobenzo[c]thiophenes 346
IV. Benzo[c[thiophene 361
V. Alkyl and Aryl Derivatives of Benzo[c]thiophene 366
VI. Hydrobenzo[c]thiophene 2-Oxides and 2,2-Dioxides 371
VII. 2-Thiophthalide, Phthalic Thioanhydride, and Related Compounds Note Added in Proof 379
Author Index 394
Cumulative Index of Titles 416