Advances in Parasitology (eBook)

Cover 1
Contents 12
Contributors to Volume 63 6
Preface 8
Phylogenetic Analyses of Parasites in the New Millennium 16
Introduction 17
Some Basics 19
Interpreting Trees 23
Phylogenetic Data 43
Evolutionary Models 52
Tree-Building 68
Combining Data Sets 80
Worked Example 88
Summary Protocol for Molecular Sequences 110
References 112
Targeting of Toxic Compounds to the Trypanosome’s Interior 140
Introduction 142
Uptake and Action of Current Trypanocidal Drugs 143
Targeting of Novel Compounds to Trypanosomes via Plasma Membrane Transporters 157
Delivery of Drug Conjugates and Encapsulated Forms 174
Efflux Pumps 176
Conclusion 177
Acknowledgements 178
References 178
Making Sense of the Schistosome Surface 200
Introduction 201
Parasite Surface Proteins 208
Tegumental Lipid Composition 242
Tegumental Carbohydrate Composition 244
Host Molecules 247
Changes at the Surface During Parasite Maturation 264
Tegumental Membrane Dynamics 266
Praziquantel and the Tegument Surface 275
Summation 277
References 279
Immunology and Pathology of Intestinal Trematodes in Their Definitive Hosts 300
Introduction 301
Biology of the Intestinal Trematodes 306
The Family Brachylaimidae 309
The Family Diplostomidae 312
The Family Echinostomatidae 322
The Family Gymnophallidae 336
The Family Heterophyidae 343
The Family Paramphistomidae 354
Other Families of Interest 361
Concluding Remarks 362
Acknowledgments 363
References 364
Systematics and Epidemiology of Trichinella 382
Introduction 383
Advances in the Systematics of Trichinella 388
The Taxonomy of the Genus 392
Phylogeny 407
Biogeography 408
Epidemiology 411
A New Approach: Trichinella-Free Areas or Farms. is it Possible? 428
Concluding Remarks 431
Acknowledgements 432
References 432
Index 456