Advances in Immunology (eBook)

Cover 1
Copyright Page 5
Contents 6
Contributors 10
Chapter 1. Interactions Between NK Cells and B Lymphocytes 11
I. Introduction 11
II. B Lymphocytes 11
III. NK Cells 16
IV. NK–B-Cell Interactions In Vitro 20
V. In Vivo NK–B Cell Interactions 29
VI. The Role of NK–B-Cell Interactions in Autoimmune Diseases 36
VII. NK–B-Cell Interactions during Infections 38
VIII. Conclusions 41
References 41
Chapter 2. Multitasking of Helix-Loop-Helix Proteins in Lymphopoiesis 53
I. Introduction 53
II. HLH Proteins and B-Cell Development 64
III. HLH Proteins and T-Cell Development 68
IV. HLH Protein and Notch Signaling 73
V. HLH Proteins and Leukemia 74
VI. Conclusions 77
References 77
Chapter 3. Customized Antigens for Desensitizing Allergic Patients 89
I. Introduction 89
II. Allergy Diagnosis and Immunotherapy: From Extracts to Allergen Arrays and Engineered Vaccines 90
III. Novel Antigen Preparations to Improve SIT 93
IV. Customized Allergen DNA Vaccines 113
V. Short Overview of Alternative Treatments and Supporting Adjuvants for SIT 123
VI. Summary and Conclusions 125
References 126
Chapter 4. Immune Response Against Dying Tumor Cells 141
I. Introduction 141
II. Minimal Elements of the Antitumor Immune Response 143
III. Subroutines of Cell Death: Apoptosis and Necrosis 150
IV. In Vivo Immunogenicity of Apoptotic Versus Necrotic Tumor Cells 160
V. Apoptosis. A Tolerogenic Type of Tumor Cell Death? 166
VI. Strategies to Enhance the Immunogenicity of Dying Tumor Cells 169
VII. Concluding Remarks 174
References 176
Chapter 5. HMGB1 in the Immunology of Sepsis (Not Septic Shock) and Arthritis 191
I. Introduction 191
II. Modern Clinical Syndromes: Septic Shock is not Severe Sepsis 193
III. TNF is a Mediator of Septic Shock Syndrome, but Not Severe Sepsis Syndrome 194
IV. HMGB1 and Anti-HMGB1 in Severe Sepsis, Not Septic Shock 195
V. Biochemistry and Molecular Biology of HMGB1 198
VI. HMGB1 Signaling via RAGE and TLR2 201
VII. Cytokine Activities of HMGB1 202
VIII. HMGB1 in Arthritis 204
IX. Perspective and Future 205
References 206
Chapter 6. Selection of the T-Cell Repertoire: Receptor-Controlled Checkpoints in T-Cell Development 211
I. Thymic Selection. A Historical Perspective 211
II. Early T-Cell Development 217
III. Late T-Cell Development 226
IV. The Role of Thymic Selection in Recessive and Dominant Mechanisms of Self-Tolerance 232
V. Concluding Remarks 237
References 238
Chapter 7. The Pathogenesis of Diabetes in the NOD Mouse 249
I. Introduction 249
II. Origin of the NOD Mouse 249
III. Pathogenesis of Diabetes in the NOD Mouse 250
IV. Leukocytes Involved in the Pathogenesis of Diabetes in the NOD Mouse 251
V. Other Autoimmune Diseases Associated with the NOD Mouse 254
VI. Breakthough Moments in the Study of the Pathogenesis of Diabetes in the NOD Mouse 255
VII. Concluding Remarks 264
References 265
Index 275
Contents of Recent Volumes 287
Color Plate Section 292