Advances in Cancer Research (eBook)

Cover 1
Contents 6
Contributors to Volume 79 10
Chapter 1. New Paradigms for the Treatment of Cancer: The Role of Anti-Angiogenesis Agents 12
I. Introduction 13
II. Growth Factors and Receptor Tyrosine Kinases 15
III. Platelet-Derived Endothelial Cell Growth Factor/Thymidine Phosphorylase 27
IV. Matrix Metalloproteinases 29
V. Plasminogen Activator/Plasmin System 35
VI. Integrins 37
VII. Other 39
VIII. Conclusions 40
References 41
Chapter 2. The Hepatocyte Growth Factor/Met Pathway in Development, Tumorigenesis, and B-Cell Differentiation 50
I. Introduction 50
II. Structure and Function of HGF and Met 51
III. HGF/Met in B-Cell Development and Neoplasia 79
IV. Summary 86
References 86
Chapter 3. Clinical Targets for Anti-Metastasis Therapy 102
I. Introduction 103
II. Metastasis: Clinical and Experimental Considerations 104
III. New Tools for Studying the Metastatic Process 106
IV. New Insights into the Metastatic Process 111
V. Targets for Anti-Metastasis Therapy: Clinical and Biological Considerations 121
VI. Conclusions 129
References 129
Chapter 4. Animal Models of Melanoma: Recent Advances and Future Prospects 134
I. Introduction 134
II. Clinical Aspects of Melanoma 135
III. Molecular Basis for Melanoma 138
IV. Role of Receptor Tyrosine Kinases 146
V. Model Systems for Melanoma 150
VI. Conclusions 160
References 161
Chapter 5. The Indispensable Role of Microenvironment in the Natural History of Low-Grade B-Cell Neoplasms 168
I. Introduction 169
II. More Characters Are Coming on the Stage 169
III. Conclusions 181
References 181
Chapter 6. Epstein–Barr Virus Latency: LMP2, A Regulator or Means for Epstein–Barr Virus Persistence? 186
I. Introduction 187
II. EBV Latency 188
III. Latent Membrane Protein 2 189
IV. B-Cell Signal Transduction and LMP2A 194
V. LMP2A Site-Specific Mutant LCLs 196
VI. Model of LMP2A and LMP2B Function in Vitro 200
VII. In Vivo Models of LMP2A Function 202
VIII. LMP2 Function in Epithelial Cells 203
IX. Discussion 204
References 208
Chapter 7. Biochemistry and Pathological Importance of Mucin-Associated Antigens in Gastrointestinal Neoplasia 212
I. Introduction 212
II. Biochemistry and Molecular Biology of Mucins 213
III. Alterations of Mucin Peptide and Mucin Glycosylation during Carcinogenesis 227
IV. Expression of Mucin-Associated Antigens in Gastric Tissues 230
V. Expression in Colorectal Tissues 235
VI. Prognostic Relevance in Gastrointestinal Cancer 242
VII. Serum Tumor Markers (Circulating Antigens) 244
VIII. Functional Aspects Regarding Invasion and Metastasis 245
IX. Perspectives in Tumor Immunology and Cancer Therapy 247
References 249
Chapter 8. Studies on Polyomavirus Persistence and Polyomavirus-Induced Tumor Development in Relation to the Immune System 260
I. Introduction 260
II. Initial Studies on Polyomavirus Infection and Polyoma-Specific Immune Reponses in Vivo and in Vitro 261
III. Molecular Characteristics of Polyomavirus 263
IV. Polyomavirus Tumor-Specific Transplantation Antigens 264
V. Factors Influencing Polyomavirus Persistence and Polyomavirus-Induced Tumor Development 265
VI. Studies on Polyomavirus Persistence and Polyomavirus-Induced Tumor Development in Immunocompetent and Immunodeficient Mice 267
VII. Concluding Remarks 282
VIII. Future Prospects 284
References 284
Index 288