Advances in Cancer Research (eBook)

Cover 1
Copyright Page 5
Contents 6
Contributors to Volume 82 8
Chapter 1. Retinoblastoma Protein Partners 10
I. An Introduction to pRb-Binding Proteins 11
II. Potential pRb Partners 22
References 56
Chapter 2. p53-Dependent Apoptosis Pathways 64
I. p53 65
II. Bcl-2 Family 71
III. Caspase Family 76
IV. IAPs 83
V. p53-Mediated Apoptosis in Cancer Therapy 84
References 85
Chapter 3. von Hippel-Lindau Disease: Clinical and Molecular Perspectives 94
I. The VHL Gene and VHL Disease 95
II. The VHL TSG and Sporadic Cancers 103
III. Functional Analysis of The VHL Tumor Suppressor Gene 104
IV. Conclusion 110
References 110
Chapter 4. Nitric Oxide-Induced Apoptosis in Tumor Cells 116
I. Introduction 117
II. NO and Antimetastatic Resistance 118
III. Mechanisms of NO-Mediated Apoptosis 125
IV. Concluding Remarks 133
References 134
Chapter 5. Detection of Minimal Residual Disease 142
I. Introduction 143
II. Technical Aspects of the Detection of Minimal Residual Disease 144
III. MRD in Leukemia 152
IV. MRD in Lymphoma 166
V. MRD in Solid Tumors 174
VI. Concluding Remarks 179
References 181
Chapter 6. Modeling Prostate Cancer in the Mouse 196
I. Introduction 196
II. Anatomy of the Adult Prostate Gland 197
III. Embryology and Growth of the Prostate Gland 198
IV. Components of the Epithelial Compartment: Do Prostate Stem Cells Exist? 201
V. Role of Oncogenes and Tumor Suppressors in Prostate Neoplasia 203
VI. Progress in the Development of CaP Animal Models 206
References 210
Chapter 7. Immunity to Oncogenic Human Papillomaviruses 214
I. Epidemiology of Human Papillomavirus Infection 215
II. The Antibody Response to HPV Infection 216
III. Cellular Immunity to HPV Infection 223
IV. Does Cross-Protective Immunity Exist? 235
References 240
Index 248