Advances in Cancer Research (eBook)

Cover 1
Copyright Page 5
Contents 6
Contributors to Volume 80 10
Chapter 1. Involvement of Platelet-Derived Growth Factor in Disease: Development of Specific Antagonists 12
I. Introduction 13
II. Platelet-Derived Growth Factor (PDGF) and PDGF Receptors 14
III. Intracellular Signal Transduction 16
IV. In Vivo Function of PDGF 20
V. PDGF in Disease 24
VI. PDGF and PDGF Receptors as Drug Targets 30
VII. Future Perspectives 38
References 39
Chapter 2. Tumor Suppression Activity of Adenovirus E1a Protein: Anoikis and the Epithelial Phenotype 50
I. Introduction 50
II. Historical Development of E1a as a Tumor Suppressor 51
III. Epithelial Conversion: Phenomenology 52
IV. Epithelial Conversion: Mechanisms 52
V. Anoikis Sensitization and Tumor Suppression by E1a 55
References 57
Chapter 3. Comparative Analysis of the Transforming Mechanisms of Epstein–Barr Virus, Kaposi’s Sarcoma-Associated Herpesvirus, and Herpesvirus Saimiri 62
I. Introduction 62
II. Comparative Analysis of Gamma Herpesvirus Gene Products 66
III. Conclusion 83
References 84
Chapter 4. Genetic Predisposition and Somatic Diversification in Tumor Development and Progression 94
I. Introduction 95
II. Hereditary Colorectal Cancer Syndromes 96
III. Tumor Mutations and Molecular Clocks: Gateways to the Fourth Dimension 100
References 121
Chapter 5. Primary Effusion Lymphoma: A Liquid Phase Lymphoma of Fluid-Filled Body Cavities 126
I. Definition of Primary Effusion Lymphoma 127
II. Histogenes of Primary Effusion Lymphoma 130
III. Pathogenesis of Primary Effusion Lymphoma 132
IV. Epidemiology of Primary Effusion Lymphoma 144
V. Clinical Features of Primary Effusion Lymphoma 146
VI. Radioimaging of Primary Effusion Lymphoma 147
VII. Differential Diagnosis of Primary Effusion Lymphoma 147
VIII. Therapy of Primary Effusion Lymphoma 148
IX. Perspectives 149
References 151
Chapter 6. Dimensions of Antigen Recognition and Levels of Immunological Specificity 158
I. Introduction 159
II. Logical Preliminaries: Boundaries of Categories and Categories of Boundaries 160
III. Monovalent Recognition 164
IV. Multivalent Recognition 176
V. Specificity of Cellular Activation 182
VI. Organismal Specificity 185
VII. Conclusions 193
References 194
Chapter 7. Topoisomerase I-Mediated DNA Damage 200
I. Introduction 200
II. Structural Domains of Top1 201
III. Top1 Functions and Protein Interactions 202
IV. The Top1 Catalytic Cycle and Cleavage Complexes 206
V. Anticancer Top1 Poisons 209
VI. Suppression and/or Enhancement of Top1 Cleavage Complexes by DNA Damage 212
VII. Processing of Top1-Mediated Dna Lesions 220
VIII. Conclusions 222
References 222
Index 228