Advances in Cancer Research (eBook)

Cover 1
Contents 6
Contributors to Volume 81 8
Chapter 1. A Decade of Progress in Allogeneic Hematopoietic Cell Transplantation: 1990–2000 9
I. Introduction 10
II. Prophylaxis Against Graft-Versus-Host Disease 10
III. Source of Allogeneic Hematopoietic Cells 14
IV. Matched Unrelated Donor Transplantation 16
V. Transplantation of Umbilical Cord Blood Cells 19
VI. Transplantation from Haploidentical Donors 21
VII. Immunotherapy Following Relapse 23
VIII. Allogeneic Transplantation Using Nonmyeloablative Regimens 24
IX. Complications of Allogeneic Hematopoietic Cell Transplantation 27
X. Advances in Allogeneic Hematopoietic Cell Transplantation for Specific Diseases 33
XI. Conclusions and Future Directions 56
References 56
Chapter 2. A Role For Secondary V(D)J Recombination in Oncogenic Chromosomal Translocations? 69
I. Introduction 70
II. V(D)J Rearrangement 71
III. Illicit V(D)J Rearrangement Mediated by Cryptic Rss or Rss-Like Motifs 80
IV. The Germinal Center 81
V. Chromosomal Translocations in GC-Like Lymphomas 86
VI. Research 91
VII. Conclusions 94
References 95
Chapter 3. Recombinant Immunotoxins in Targeted Cancer Cell Therapy 101
I. Introduction 102
II. Design of Recombinant Immunotoxins 106
III. Construction and Production of Recombinant Immunotoxins 112
IV. Preclinical Development of Recombinant Immunotoxins 113
V. Application of Recombinant Immunotoxins 115
VI. Other Applications of Recombinant Antibody Fragments 119
VII. Challenges and Future Directions of Recombinant Immunotoxins 123
References 127
Chapter 4. Human Herpesvirus-8 and Kaposi's Sarcoma: Relationship with the Multistep Concept of Tumorigenesis 133
I. Clinical Presentation of KS 134
II. Histology of KS and Nature of KS Spindle Cells 135
III. HHV-8 and KS 136
Iv. Conclusion 156
References 158
Chapter 5. Reactivation and Role of HHV-8 in Kaposi's Sarcoma Initiation 169
I. Kaposi S Sarcoma 170
II. Risk Factors Associated with KS Development 172
III. Histology of KS and Origin of Spindle Cells 174
IV. HHV-8 Infection in KS Lesions 177
V. KS Initiation: Role of IC in KS Histogenesis and HHV-8 Infection 178
VI. Lack of Control of Reactivated HHV-8 189
VII. KS Progression: Oncogenes, Oncosuppressor Genes, HHV-8 Latency Genes, and the HIV-1 Tat Protein 192
VIII. Concluding Remarks 195
References 196
Index 209