Advances in Drug Research (eBook)

Cover 1
Advances in Drug Research 4
Copyright Page 5
CONTENTS 6
Contributors 8
Preface 10
Chapter 1. Complexity and Emergence in Drug Research 14
1. General Background 15
2. Some Complex Systems of Interest in Drug Research 25
3. Applications to Drug Research 39
4. Concluding Remarks 50
References 52
Recommended Reading 54
Chapter 2. Drug Design: the Present and the Future 58
1. Introduction 59
2. Goals of Design 60
3. Methods of Design 91
4. The Future 144
References 147
Chapter 3. Transgenic Animals as Pharmacological Tools 156
1. Introduction 157
2. Methods to Generate Genetically Modified Animals 160
3. Gain-of-function Models 170
4. Loss-of-function Models 173
5. Pharmacological Models 178
6. Outlook 183
References 185
Chapter 4. Xenobiotic-metabolizing Human Cells as Tools for Pharmacological and Toxicological Research 192
1. Introduction 193
2. In vitro Systems 196
3. General Approaches to cDNA Expression 203
4. Challenges 207
5. Criteria for Validation 215
6. State of the Art 218
7. Example of Applications 233
8 Prospects for the Future 241
References 242
Chapter 5. Correlates of Variable Patient Compliance in Drug Trials: Relevance in the New Health Care Environment 250
1. Introduction 251
2. Overview of Changes in the Health Care Environment 251
3. Patterns of Misuse and Their Consequences 254
4. Defining Patient Compliance 255
5. Methodological Advances 258
6. Compliance Measurement in Clinical Trials 259
7. Conclusion 267
References 268
Subject Index 272
Cumulative Index of Authors 286
Cumulative Index of Titles 290