Oncology (eBook)

Foreword 6
Preface 11
Contents 13
Contributors 21
Principles of Oncology 40
Evidence-Based Approach to Oncology 41
Principles of Chemotherapy 52
Principles of Radiation Oncology 79
Principles of Surgical Therapy in Oncology 96
Principles of Targeted and Biological Therapies 111
Biologic Principles of Hematopoietic Stem Cell Transplantation 129
Evaluation of Tumor Markers: An Evidence- Based Guide for Determination of Clinical Utility 144
Design and Analysis of Oncology Clinical Trials 150
Ethics of Clinical Oncology Research 165
Informatics Infrastructure for Evidence- Based Cancer Medicine 181
Economics of Cancer Care 189
Principles of Screening for Cancer 199
Patient Decision Making 215
Establishing an Interdisciplinary Oncology Team 222
Principles of Complementary and Alternative Medicine for Cancer 232
Translational Basic Science 242
Fundamental Aspects of the Cell Cycle and Signal Transduction 243
Viral Carcinogenesis 250
Environmental Carcinogenesis 269
Cancer Metastasis 280
Tumor Immunology and Immunotherapy 290
Technologies in Molecular Biology: Diagnostic Applications 305
Cancer Prevention and Control 321
Cancer Epidemiology 322
Evidence-Based Cancer Prevention Research: A Multidisciplinary Perspective on Cancer Prevention Trials 336
Screening 352
Genetic Screening and Counseling for High- Risk Populations 376
Behavior Modification 393
Cancer Imaging 402
Central Nervous System Imaging 403
Breast Imaging 415
Imaging of Thoracic Malignancies 426
Imaging of Gastrointestinal Stromal Tumor 447
Genitourinary Imaging 459
Musculoskeletal Imaging 476
Positron Emission Tomography and Cancer 483
Solid Tumors 518
Central Nervous System Tumors 519
Eye, Orbit, and Adnexal Structures 538
Head and Neck Cancer 566
Lung Cancer 583
Therapy for Malignant Pleural Mesothelioma 660
Mediastinum 683
Esophageal Cancer 702
Stomach 718
Colon, Rectal, and Anal Cancer Management 742
Adenocarcinoma and Other Small Intestinal Malignancies 771
Cancer of the Liver and Bile Ducts 783
An Evidence-Based Approach to the Management of Pancreatic Cancer 802
Renal Cell Cancer 820
Ureter, Bladder, Penis, and Urethra 844
Prostate Cancer 864
Testis Cancer 882
Cervix, Vulva, and Vagina 912
Gestational Trophoblastic Neoplasia 930
Ovarian Cancer 941
Uterine Malignancies 968
Evidence-Based Management of Breast Cancer 991
Thyroid and Parathyroid 1023
Tumors of the Endocrine System 1045
Sarcomas of Bone 1065
Soft Tissue Sarcoma 1079
Cutaneous Melanoma 1113
Nonmelanoma Cutaneous Malignancies 1133
Cancer of Unknown Primary Site 1150
Solid Tumors of Childhood 1164
Hematologic Malignancies 1188
Acute Myeloid Leukemia and the Myelodysplastic Syndromes 1189
Acute Lymphoblastic Leukemia 1211
Chronic Lymphocytic Leukemia and Related Chronic Leukemias 1239
Chronic Myeloid Leukemia 1258
An Evidence-Based Approach to the Management of Hodgkin’s Lymphoma 1269
The Non-Hodgkin’s Lymphomas 1285
Multiple Myeloma 1314
Practice of Oncology 1326
Superior Vena Cava Syndrome 1327
Central Nervous System Emergencies 1335
Metabolic Emergencies in Oncology 1348
Surgical Emergencies 1359
Oral Complications of Cancer Therapy 1376
Alopecia and Cutaneous Complications of Chemotherapy 1390
Infectious Complications of Cancer Therapy 1399
Acute Toxicities of Therapy: Pulmonary Complications 1437
Cardiac Complications 1447
Neurologic Complications of Therapy 1454
Acute Toxicities of Therapy: Urologic Complications 1462
Issues in Vascular Access with Special Emphasis on the Cancer Patient 1470
Management of Cancer Pain 1482
Nausea and Vomiting in the Cancer Patient 1509
Nutritional Support for the Cancer Patient 1524
Paraneoplastic Syndromes 1542
Malignant Effusions 1554
Evidence-Based Use of Hematopoietic Growth Factors for Optimal Supportive Care of Patients with Cancer 1562
Management of the Bone Marrow Transplant Patient 1572
Management of Anxiety and Depression in Adult Cancer Patients: Toward an Evidence- Based Approach 1588
Reproductive Complications and Sexual Dysfunction in the Cancer Patient 1616
The Care of the Terminal Patient 1637
Metastatic Cancer to the Central Nervous System 1648
Metastatic Cancer to Lung 1662
Surgical and Regional Therapy for Liver Metastases 1672
Metastatic Cancer to Bone 1691
Cancer in the Immunosuppressed Patient 1716
Cancer in the Older Population 1744
Chemotherapy in Patients with Organ Dysfunction 1757
Management of the Pregnant Cancer Patient 1774
Cancer Survivorship 1787
Survivorship Research: Past, Present, and Future 1788
Late Effects of Cancer Treatments 1803
Medical and Psychosocial Issues in Childhood Cancer Survivors 1826
Medical and Psychosocial Issues in Hodgkin’s Disease Survivors 1839
Medical and Psychosocial Issues in Testicular Cancer Survivors 1850
Medical and Psychosocial Issues in Gynecologic Cancer Survivors 1863
Medical, Psychosocial, and Health- Related Quality of Life Issues in Breast Cancer Survivors 1871
Medical and Psychosocial Issues in Prostate Cancer Survivors 1894
Physical and Psychosocial Issues in Lung Cancer Survivors 1906
Cancer Survivorship Issues in Colorectal Cancer 1926
Medical and Psychosocial Issues in Transplant Survivors 1937
Second Malignancies After Radiation Treatment and Chemotherapy for Primary Cancers 1964
Psychosocial Rehabilitation in Cancer Care 1977
Cancer Advocacy 1990
Index 1994