Hereditary Factors in Carcinoma

1 History of Cancer Genetics in Man.- Man as a problem for genetic studies.- Cancer genetics in animals.- Early studies in man.- Cancer of specific anatomic sites.- Twin studies.- Cancer families.- Mendelian inherited cancer disorders.- Cytogenetics and carcinoma.- Blood group antigens and carcinoma.- Cancer resistance.- References.- 2 Classical Examples of Heredity and Malignancy.- Familial polyposis coli.- Gardner's syndrome.- Multiple nevoid basal cell carcinoma syndrome.- Xeroderma pigmentosum.- Thyroid carcinoma (medullary thyroid carcinoma with amyloid production associated with pheochromocytoma)..- Hereditary multiple exostoses.- Hereditary polyendocrine adenomatoses and the Zollinger-Ellison syndrome.- Tylosis and esophageal cancer (keratosis palmaris et plantaris).- Bloom's syndrome (congenital telangiectatic erythema and stunted growth).- Fanconi's aplastic anemia (constitutional aplastic anemia).- Retinoblastoma.- Von Recklinghausen's neurofibromatosis.- References.- 3 Heredity and the More Common Malignancies of Man: Carcinoma of the Breast, Stomach, Colon, Lung, Prostate, and Endometrium.- Breast Cancer.- Stomach Cancer.- Colon carcinoma.- Solitary polyps of the rectum and colon.- Turcot's syndrome.- Ulcerative colitis and carcinoma of the colon.- Juvenile polyposis coli.- Colon carcinoma in the absence of polyps.- Lung carcinoma.- Prostate carcinoma.- Endometrial carcinoma.- References.- 4 Hereditary Aspects of Some Less Frequently Occuring Malignancies Exclusive of the Reticuloendothelial System.- Kaposi's sarcoma.- Carcinoma of the nasopharynx.- Carotid body tumors.- Generalized keratoacanthoma.- Hepatocellular carcinoma.- Familial pheochromocytoma.- Malignant melanoma.- Carcinoid tumor.- Carcinoma of the duodenum.- Hypernephroma.- Testicular tumors.- References.- 5 Hereditary Disorders with Variable Malignant Neoplastic Predisposition.- Werner's syndrome.- Paget's disease (osteitis deformans) and osteogenic sarcoma.- Ataxia telangiectasia (Louis-Bar syndrome).- Congenital sex-linked agammaglobulinemia (Bruton's type).- Chediak-Higashi syndrome.- Wiskott-Aldrich syndrome.- Dermatomyositis.- Sjogren's syndrome.- Scleroderma (progressive systemic sclerosis).- Albinism.- Dysgenetic gonads and disorders of somatosexual disturbance.- Peutz-Jeghers syndrome.- Porphyria cutanea tarda.- Systemic lupus erythematosus.- References.- 6 Genetic Aspects of Tumors of the Nervous System.- Familial isolated tumors of the nervous system.- Established genetic diseases with significant incidence of tumors of nervous system...- Von Recklinghausen's neurofibromatosis.- Neurofibromas.- Sarcomatous neurofibromas.- Central and peripheral forms of neurofibromatosis.- Intracranial tumors.- Intracranial neurofibromas.- Meningiomas.- Glioma of optic nerve.- Other intracerebral tumors.- Disseminated gliosis.- Intraspinal tumors.- Multiple primary intracranial and intraspinal neoplasms.- Pheochromocytoma.- Von Hippel Lindau's hemangioblastoma.- Anatomic sites of hemangioblastomas.- Tuberous sclerosis.- Hereditary multiple endocrine adenomatosis.- Multiple nevoid basal cell carcinoma syndrome.- Retinoblastoma.- Pheochromocytoma.- Neuroblastoma.- Summary.- 7 Heredity and Malignancies of the Reticuloendothelial System.- Hodgkin's disease.- Multiple myeloma.- Leukemia.- Early genetic studies.- Chronic lymphocytic leukemia and Ch1 chromosome.- Chronic myelogenous leukemia and Ph1 chromosome.- Waldenstrom's macroglobulinemia.- References.- 8 Congenital Cancer and Congenital Abnormalities Associated with Cancer.- Introductory survey.- Neuroblastoma.- Wilm's tumor.- Aniridia.- Hemihypertrophy.- Adrenal cortical carcinoma.- Hepatic carcinoma.- Wilm's tumor.- Neuroblastoma.- Klinefelter's and Turner's syndromes.- Congenital epithelial parotid gland tumors.- References.- 9 "Cancer Families": Adenocarcinomas (Endometrial and Colon Carcinoma) and Multiple Primary Malignant Neoplasms.- and historical review.- Definition of a "cancer family".- Importance of histologic diagnosis.- Study of six "cancer families".- Heredity and multiple primary malignant neoplasms.- Cancer families in the literature from Warthin (Family G) to present.- The hereditary multiple cancer syndrome.- Implications for this cancer syndrome from the standpoint of early cancer detection and cancer control.- References.- 10 Heredity, Emotions, and Carcinoma: Delay in Cancer Detection.- Tumor service Patient series.- Two "cancer families".- College Alumnae series.- Analysis of findings.- Implications for cancer control.- References.- 11 Cancer and Genetic Counseling.- History of genetic counseling.- Genetic counseling and diagnosis.- Genetic counseling, physician responsibility, a patient-physician relationship.- Genetic counseling as "family problems".- Clinical examples, emotional and psychiatric factors.- Protocol for genetic counseling.- Genetic terminology and disease.- Phenocopies.- Penetrance.- Variable expressivity.- Genetic counseling and cancer patients.- Family with xeroderma pigmentosum.- Cancer family.- Familial polyposis coli.- Summary.- References.- 12 Epilogue.- Figures.