Handbook of Experimental Pharmacology / Estrogens and Antiestrogens I

These volumes cover all relevant aspects of recent research in estrogens and antiestrogens from chemistry, physiology, pharmacology to clinical applications. Particular emphasis is devoted to new developments in the area of estrogen receptors including estrogen receptor ß and the mode of action of novel partial estrogen agonists/antagonists. Further topics address the importance of estrogens and anti- estrogens in fertility, aging, cancer, animal husbandry and environment. Part II extends the information from Part I addressing the broad variety of pharmacological activities, their kinetics and toxicology. Particular emphasis is placed on the potential of these compounds in an impressive number of clincial indications. The chapters have been written by internationally renowned experts in their fields. Due to their broad scope, these volumes will be indispensable reference books in any library. TOC:Part I: Chemistry of Estrogens and Antiestrogens; Molecular Biology of Estrogenic Action; Biosynthesis and Metabolism of Endogenous Estrogens; Physiology and Pathophysiology of Estrogens.- Part II: Pharmacology of Estrogens and Antie- strogens; Toxicology of Estrogens and Antiestrogens; Clini- cal Application and Potential of Estrogens and Antiestro- gens; Comparative Endocrinology; Estrogens, Antiestrogens and Environment.